目的 探究乌司他丁联合生长抑素治疗重症急性胰腺炎的临床疗效.方法 便利选取山东省济南市章丘区中医医院于2019年6月—2023年9月收治的78例重症急性胰腺炎患者为研究对象,采用密闭信封法分为对照组和研究组,各39例.所有患者均采用常规治疗,对照组在此基础上使用生长抑素,研究组在对照组基础上静脉注射乌司他丁.对比两组临床疗效及不良反应发生率,检测肿瘤坏死因子-α、白细胞介素-6、C反应蛋白、淀粉酶、谷丙转氨酶、肌酐水平,并对比生活质量简表(World Health Organization Quality of Life-100,WHOQOL-100)评分.结果 研究组治疗总有效率为97.44%,高于对照组,差异有统计学意义(χ2=3.924,P=0.048).治疗后,研究组各项血清指标水平低于对照组,差异有统计学意义(P<0.001).两组不良反应发生率对比,差异无统计学意义(P>0.05).治疗后,研究组WHOQOL-100评分高于对照组,差异有统计学意义(P<0.05).结论 重症急性胰腺炎患者应用乌司他丁联合生长抑素治疗效果显著,可提高治疗有效率,改善血清指标水平,用药安全性较高,从而提高患者生活质量.
Clinical Effect of Ulinastatin Combined with Somatostatin in Treatment of Severe Acute Pancreatitis
Objective To explore the clinical effect of ulinastatin combined with somatostatin in the treatment of se-vere acute pancreatitis.Methods A total of 78 patients with severe acute pancreatitis admitted to Zhangqiu District Hospital of Traditional Chinese Medicine,Jinan City,Shandong Province from June 2019 to September 2023 conve-niently were selected as the research objects.They were divided into control group and study group by closed envelope method,with 39 cases in each group.All patients received conventional treatment,the control group received soma-tostatin on the basis of this,and the study group received ulinastatin on the basis of the control group.The clinical effi-cacy and incidence of adverse reactions were compared between the two groups.The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP),amylase(AMY),alanine aminotransferase(ALT)and creati-nine(Cr)were detected.The World Health Organization Quality Of Life-100(WHOQOL-100)score was compared.Results The total effective rate of the study group was 97.44%,which was higher than that of the control group,and the difference was significantly significant(χ2=3.924,P=0.048).After treatment,the levels of serum indexes in the study group were lower than those in the control group,and the difference was significantlly significant(P<0.001).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the WHOQOL-100 score of the study group was higher than that of the control group,and the difference was statistically significantly significant(P<0.05).Conclusion Ulinastatin combined with somatostatin has a significant effect in the treatment of patients with severe acute pancreatitis,which can improve the treatment efficiency and serum index level and has high drug safety,so as to improve the quality of life of patients.
UlinastatinSomatostatinSevere acute pancreatitisEffective rate of treatmentSerum index level
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万方数据
维普
