鼻内镜修补术对脑脊液鼻漏患者住院时间及并发症的影响
Effect of Nasal Endoscopic Repair on Length of Stay and Complications in Patients with Cerebrospinal Fluid Rhinorrhea
吴玲心 1李帅 2张党林2
作者信息
- 1. 南京医科大学附属江宁医院耳鼻咽喉科,江苏南京 211100
- 2. 南京医科大学附属江宁医院神经外科,江苏南京 211100
- 折叠
摘要
目的 对比研究鼻内镜修补术与传统颅内修补术治疗脑脊液鼻漏的临床疗效.方法 方便选取2021年1月—2022年12月南京医科大学附属江宁医院收治的162例脑脊液鼻漏患者为研究对象,采用随机数表法分为对照组(n=81)、研究组(n=81).对照组行传统颅内修补术,研究组行鼻内镜修补术.分别于术前及术后2 d,检测两组肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、C反应蛋白(C-reactive Protein,CRP)、白介素-6(Interleukin-6,IL-6)水平,比较两组手术成功率、住院时间、并发症发生情况.结果 研究组手术成功率(96.29%)高于对照组(87.65%),差异有统计学意义(χ2=4.098,P<0.05);研究组住院时间短于对照组,差异有统计学意义(P<0.001);术前,两组炎性因子水平对比,差异无统计学意义(P>0.05);术后研究组TNF-α、CRP、IL-6水平均低于对照组,差异有统计学意义(P均<0.001);研究组并发症发生率低于对照组,差异有统计学意义(P<0.05).结论 鼻内镜修补术在治疗脑脊液鼻漏方面表现出显著的优势.手术成功率较高,手术过程对炎性因子水平影响较小,能够缩短患者住院时间,且术后并发症风险较低,对于改善患者的预后有积极作用.
Abstract
Objective To compare the clinical effect of nasal endoscopic repair and traditional intracranial repair in the treatment of cerebrospinal fluid rhinorrhea.Methods A total of 162 patients with cerebrospinal fluid rhinorrhea ad-mitted to Jiangning Hospital Affiliated to Nanjing Medical University from January 2021 to December 2022 were con-veniently selected as the study objects,and were divided into control group(n=81)and study group(n=81)by random number table method.The control group underwent traditional intracranial repair,and the study group underwent na-sal endoscopic repair.The levels of Tumor Necrosis Factor-α(TNF-α),C-reactive Protein(CRP)and Interleukin-6(IL-6)in the two groups were detected before and 2 days after surgery,respectively.The operation success rate,hospi-tal stay and complications were compared between the two groups.Results The success rate of operation in the study group(96.29%)was higher than that in the control group(87.65%),and the difference was statistically significant(χ2= 4.098,P<0.05).The duration of hospitalization in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.001).Before operation,there was no significant difference in the levels of inflammatory factors between the two groups(P>0.05).After operation,the levels of TNF-α,CRP and IL-6 in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.001).The complication rate of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Endoscopic nasal repair has shown significant advantages in the treatment of cerebro-spinal fluid rhinorrhea.Its success rate of surgery is higher,the operation process has less impact on inflammatory fac-tors,can shorten the length of hospital stay of patients,and the risk of postoperative complications is lower,which has a positive effect on improving the prognosis of patients.
关键词
鼻内镜修补术/脑脊液鼻漏/手术成功率/住院时间/炎性因子/并发症Key words
Nasal endoscopic repair/Cerebrospinal fluid rhinorrhea/Operation success rate/Length of hospital stay/Inflammatory factor/Complication引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据