Effects of Dexmedetomidine Combined with Sevoflurane on Anesthesia and Postoperative Cognitive Function in Patients undergoing Laparoscopic Surgery
Objective To analyze the anesthetic effect of combined dexmedetomidine in laparoscopic patients with sevoflurane anesthesia,and the preventive value of this anesthesia program on postoperative cognitive dysfunction.Methods A total of 90 laparoscopic surgery patients admitted to Youxi County Traditional Chinese Medicine Hospital in Sanming City at Fujian Province from January 2022 to March 2023 were randomly selected as the study objects and divided into control group and observation group by random number table method,with 45 cases in each group.Sevo-flurane was used in the control group,and dexmedetomidine was used in the observation group in combination with the control group.Anesthetic effect,hemodynamic indexes,serum epinephrine,norepinephrine,cortisol levels and cog-nitive function were compared between the two groups.Results Compared with the control group,the observation group was shorter in terms of postoperative waking time,first breathing time and orientation recovery time,and the dif-ferences were statistically significant(all P<0.05).Compared with before surgery,the hemodynamic indexes and the levels of epinephrine,norepinephrine and cortisol in control group at 6 h and 12 h after surgery were significantly de-creased,and the differences were statistically significant(all P<0.05).The hemodynamic indexes and the levels of epi-nephrine,norepinephrine and cortisol in control group at 6 h and 12 h after surgery were significantly lower than those in observation group,and the differences were statistically significant(all P<0.05).On the first day after operation,the cognitive function score of the observation group was significantly higher than that of the control group,and the differ-ence was statistically significant(P<0.05).Conclusion The combination of sevoflurane and dexmedetomidine in pa-tients undergoing laparoscopic surgery can achieve better anesthetic effects and significantly reduce postoperative cog-nitive dysfunction.
DexmedetomidineSevofluraneLaparoscopic surgeryAnesthetic effectPostoperative cognitive function
万方数据
维普
