Efficacy and Liver Function of Somatostatin Combined with Thrombin in the Treatment of Upper Gastrointestinal Bleeding Associated with Cirrho-sis
Objective To study the effect of somatostatin assisted thrombin in the treatment of cirrhosis associated up-per gastrointestinal bleeding(UGIB).Methods A total of 80 cirrhosology-related UGIB patients admitted to the Gas-troenterology Department of Xinyi People's Hospital of Jiangsu Province from October 2022 to October 2023 were simple randomly selected as the study objects.They were divided into two groups by random number table method.The conventional group(n=40)was treated with somatostatin,and the combined group(n=40)was treated with throm-bin on the basis of the control group.The clinical indexes,therapeutic effect,coagulation function,liver function and incidence of adverse reactions were compared between the two groups.Results The clinical indexes of combined group were better than those of conventional group,and the differences were statistically significant(all P<0.05).The total ef-fective rate of the combined group(100.00%)was higher than that of the conventional group(87.50%),and the differ-ence was statistically significant(χ2=5.333,P=0.021).Thrombin time,activated partial thrombin time and prothrom-bin time in combination group were shorter than those in conventional group,while fibrinogen time was higher than that in conventional group,and the differences were statistically significant(all P<0.05).The glutamic oxalic amino-transferase and alanine aminotransferase in combination group were lower than those in conventional group,and cho-linesterase was higher than those in conventional group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Somatostatin combined with thrombin therapy in cirrhosis related UGIB patients can regulate clinical indicators,en-hance efficacy,improve coagulation function and liver function,and have few side effects,so it is suitable for further promotion.
万方数据
维普
