Clinical Efficacy of Sacubactril Valsartan Sodium Tablets Combined with Metoprolol Succinate Sustained-release Tablets in the Treatment of Coro-nary Atherosclerotic Heart Disease Complicated with Chronic Heart Fail-ure
Objective To explore the clinical efficacy of sacubactril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets in the treatment of coronary atherosclerotic heart disease complicated with chronic heart failure.Methods A total of 223 patients with coronary atherosclerotic heart disease combined with chronic heart failure admitted to Sanming Shaxian District General Hospital from January 2021 to September 2023 were conve-niently selected as the study objects and were randomly divided into the control group(n=111)and the study group(n=111)according to the method of random number table.Metoprolol succinate sustained-release tablets was used in the control group and metoprolol succinate sustained-release tablets+sacubactril valsartan sodium tablets were used in the stusy group.The clinical effect,cardiac function,myocardial injury serum index and blood pressure were com-pared between the two groups.Results The clinical effective rate of the study group was 98.21%,which was higher than 90.99%of the control group,and the difference was statistically significant(χ2=5.713,P=0.017).The improve-ment of cardiac index,left ventricular ejection fraction and cardiac output in the study group after treatment were bet-ter than those in the control group,and the differences were statistically significant(all P<0.05).The N terminal pro-B type natriuretic peptide and matrix metalloproteinases-9 in the study group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The reduction of diastolic blood pressure and systolic blood pressure in the study group were greater than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion Sacubactril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets have a significant effect in the treatment of patients with coronary atherosclerotic heart dis-ease complicated with chronic heart failure,which can reduce myocardial damage,improve cardiac function and re-duce blood pressure.
万方数据
维普
