首页|甲磺酸奥希替尼对比埃克替尼治疗非小细胞肺癌的临床效果分析

甲磺酸奥希替尼对比埃克替尼治疗非小细胞肺癌的临床效果分析

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目的 分析非小细胞肺癌患者实施甲磺酸奥希替尼片治疗干预的效果及应用价值.方法 方便选取2021年1月—2023年5月巨野县人民医院收治的88例非小细胞肺癌患者为研究对象,采用随机数表法分为研究组与参照组,各44例.参照组使用埃克替尼治疗,研究组使用甲磺酸奥希替尼片治疗,比较两组患者的疗效、血清癌胚抗原(Carcinoembryonic Antigen,CEA)、细胞角蛋白 19片段(Cytokeratin 19 Fragment Antigen 21-1,CYFRA21-1)水平变化情况和不良反应发生情况.结果 研究组治疗总有效率(100.00%)高于参照组(75.00%),差异有统计学意义(χ2=12.571,P<0.05).治疗后,研究组CEA、CYFRA21-1水平均低于参照组,差异有统计学意义(P均<0.05).研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05).结论 对非小细胞肺癌患者实施甲磺酸奥希替尼片治疗可明显降低CEA、CYFRA21-1水平及不良反应发生率,且能够提高疗效.
Clinical Efficacy of Ohitinib Mesylate Versus Ectinib in the Treatment of Non-small Cell Lung Cancer
Objective To analyze the therapeutic effect and application value of ocitinib mesylate tablets in patients with non-small cell lung cancer(NSCLC).Methods A total of 88 patients with NSCLC admitted to Juye County People's Hospital from January 2021 to May 2023 were conveniently selected as the study objects,and they were di-vided into a study group and a reference group according to the method of random number table,with 44 cases in each group.The reference group was treated with ectinib,while the study group was treated with ohitinib mesylate tablets.The curative effect,serum carcinoembryonic antigen(CEA),cytokeratin 19 fragment antigen 21-1(CYFRA21-1)and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the study group(100.00%)was higher than that in the reference group(75.00%),and the difference was statistically sig-nificant(χ2=12.571,P<0.05).The levels of CEA and CYFRA21-1 in the study group after treatment were lower than those in the reference group,and the differences were statistically significant(both P<0.05).The incidence rate of ad-verse reactions in the study group was lower than that in the reference group,and the difference was statistically sig-nificant(P<0.05).Conclusion The treatment of ohetinib mesylate tablets in patients with non-small cell lung cancer has a significant effect on reducing CEA,CYFRA21-1 levels and incidence of adverse reactions,and can improve the therapeutic effect of patients.

Ohitinib mesylate tabletsNon-small cell lung cancerAdverse reaction

陈建华、徐文浩、石翔

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巨野县人民医院肿瘤科,山东菏泽 274900

巨野县人民医院重症监护室,山东菏泽 274900

巨野县人民医院胸外科,山东菏泽 274900

甲磺酸奥希替尼片 非小细胞肺癌 不良反应

2024

中外医疗
卫生部医院管理研究所 二十一世纪联合创新医药科学研究院

中外医疗

影响因子:0.909
ISSN:1674-0742
年,卷(期):2024.43(9)