Evaluation of Effects of Remazolam on Stress Response Indexes and Post-operative Cognitive Function in Elderly Patients Undergoing Laparoscopic Surgery
Objective To explore the effects of remazolam on stress response indexes and postoperative cognitive func-tion in elderly patients undergoing laparoscopic surgery.Methods Fifty elderly patients with laparoscopic surgery ad-mitted to Tai'an Cancer Prevention and Control Hospital of Shandong Province from January 2020 to January 2023 were simple and randomly selected as the study objects,and they were divided into study group and control group ac-cording to the random number table method,with twenty-five cases in each group.In the study group,0.15 mg/kg rem-azolam was injected intravenously during anesthesia induction,while the same amount of normal saline was injected in the control group.The disappearance time of eyelash reflex,the time for bispectral idex(BIS)to fall to the target range,the postoperative cognitive function and the incidence of complications were compared between the two groups.Results The disappearance time of eyelash reflex(29.26±3.28)s and the time for BIS to target range(52.65±2.39)s in the study group were significantly shorter than those in the control group of(57.12±1.67)s and(79.24±2.58)s,and the differences were statistically significant(t=37.846,37.803,both P<0.05).The postoperative cognitive function of the study group was significantly better than that of the control group,and the difference was statistically significant(t=10.500,P<0.05).The total incidence of complications in the study group(8.00%)was significantly lower than that in the control group(32.00%),and the difference was statistically significant(χ2=4.500,P<0.05).Conclusion For elderly patients undergoing laparoscopic surgery,the use of remazolam can effectively shorten the disappearance time of eye-lash reflex and the time for BIS to fall to the target range.It can reduce the incidence of complications,improve post-operative cognitive function of patients.
RemazolamElderlyLaparoscopic surgeryStress response indexPostoperative cognitive function
NETL
NSTL
万方数据
