Clinical Analysis of Reduced Glutathione Combined with Nucleoside Ana-logues in the Treatment of Hepatitis B Cirrhosis
Objective To explore the therapeutic effect of reduced glutathione combined with nucleoside analogues in patients with hepatitis B cirrhosis.Methods 60 patients with hepatitis B cirrhosis admitted to Nantong Third People's Hospital from February 2020 to February 2023 were randomly selected as the study objects.They were divided into the study group and the reference group by the method of blind touch double color ball,with 30 cases in each group.The reference group received conventional treatment,while the study group received glutathione combined with nucleoside analogues.The clinical efficacy,degree of liver fibrosis,liver function and occurrence of adverse reactions were compared between groups.Results Before intervention,there was no statistically significant difference in the de-gree of liver fibrosis and liver function levels between the two groups(both P>0.05).After intervention,the total effec-tive rate of clinical treatment in the study group(96.67%)was higher than that in the reference group(80.00%),and the difference was statistically significant(χ2=4.043,P<0.05).After intervention,the levels of laminin(LN),hyal-uronic acid(HA),and type Ⅳ collagen(Ⅳ-C)in the liver fibrosis degree of the study group were lower than those of the reference group,and the differences were statistically significant(all P<0.05).After intervention,the total bilirubin(TBIL),albumin(ALB),glutamic pyruvic transaminase(GPT),and glutamic oxaloacetic transaminase(GOT)levels in the liver function of the study group were better than those of the reference group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions be-tween the two groups(P>0.05).Conclusion Treatment with reduced glutathione combined with nucleoside analogues can improve the therapeutic effect,the degree of liver fibrosis and the level of liver function in patients with hepatitis B cirrhosis,with high safety.
Reduced glutathioneNucleoside analogsHepatitis B cirrhosisClinical effectDegree of liver fibrosisLiver function
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