首页|阿奇霉素用药基础上联合沙丁胺醇和布地奈德雾化吸入治疗支原体感染诱发的小儿哮喘的临床研究

阿奇霉素用药基础上联合沙丁胺醇和布地奈德雾化吸入治疗支原体感染诱发的小儿哮喘的临床研究

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目的 研究在支原体感染诱发的小儿哮喘治疗期间使用沙丁胺醇和布地奈德雾化吸入与口服阿奇霉素进行联合治疗所取得的临床效果.方法 随机选取2018年1月—2021年1月闽清县总医院收治的120例支原体感染诱发哮喘的患儿为研究对象,以随机数表法分为两组,每组60例.对照组使用口服阿奇霉素+雾化吸入布地奈德雾进行治疗,研究组使用沙丁胺醇和布地奈德雾化吸入与口服阿奇霉素联合进行治疗,对比两组患者治疗情况.结果 研究组治疗总有效率为98.33%,高于对照组的88.33%,差异有统计学意义(χ2=4.821,P<0.05).研究组肺部湿啰音消失用时、气促消失用时、咳嗽消失用时均短于对照组,差异有统计学意义(P均<0.05).两组患儿不良反应总发生率对比,差异无统计学意义(P>0.05).治疗后,两组患儿生活质量评分均有所提升,且研究组高于对照组,差异有统计学意义(P<0.05).结论 在支原体感染的小儿哮喘治疗期间,在应用阿奇霉素治疗的基础上联合应用沙丁胺醇和布地奈德雾化吸入治疗,有利于提升患儿治疗综合水平.
Clinical Study of Azithromycin Combined with Salbutamol and Budesonide Aerosol Inhalation in the Treatment of Pediatric Mycoplasma Infantile Asthma
Objective To investigate the clinical effect of the combination of aerosol inhalation of salbutamol and budesonide with oral azithromycin during the treatment of pediatric asthma induced by mycoplasma infection.Methods A total of 120 children with asthma caused by mycoplasma infection admitted to Minqing County General Hospital from January 2018 to January 2021 were randomly selected as the study objects.They were divided into two groups,with 60 cases in each group by random number table method.The control group was treated with oral azithromycin+aerosol in-halation budesonide fog,while the study group was treated with aerosol inhalation of salbutamol and budesonide com-bined with oral azithromycin.The situation after treatment between the two groups were compared.Results The total ef-fective rate of the study group was 98.33%,which was higher than 88.33%in the control group,and the difference was statistically significant(χ2=4.821,P<0.05).The time for disappearance of lung moist rales,dyspnea,and cough in the study group were shorter than those of the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in total incidence of adverse reactions between the two groups of pa-tients(P>0.05).After treatment,the quality of life of the patients improved in two groups,and the study group had higher score than the control group,and the differences were statistically significant(both P<0.05).Conclusion During the treatment of mycoplasma infected children with asthma,on the basis of azithromycin treatment,the application of atomized inhalation combined with salbutamol and budesonide is conducive to improving the comprehensive treatment level of children.

Mycoplasma infectionPediatric asthmaMedicationSalbutamolBudesonideAzithromycin

吴斌、俞希杨、林晓琴

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闽清县总医院药学部,福建福州 350800

闽清县总医院儿科,福建福州 350800

支原体感染 小儿哮喘 药物治疗 沙丁胺醇 布地奈德 阿奇霉素

2024

中外医疗
卫生部医院管理研究所 二十一世纪联合创新医药科学研究院

中外医疗

影响因子:0.909
ISSN:1674-0742
年,卷(期):2024.43(10)
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