Effect Analysis of Acyclovir Combined with Human Immunoglobulin in Treatment of Viral Encephalitis
Objective To analyze the therapeutic effect of acyclovir combined with human immunoglobulin virus en-cephalitis in children.Methods A total of 90 children with viral encephalitis admitted to the Department of Pediatrics of Quanzhou First Hospital from June 2022 to June 2023 were randomly selected as the study objects.They were di-vided into two groups with 45 cases in each group by random number table method.The control group was treated with acyclovir intervention,and the observation group was treated with acyclovir combined with human immunoglobulin in-tervention.The recovery of various indexes,the level of inflammatory factors and clinical effects,the treatment effec-tiveness,the incidence of adverse reactions of the two groups were compared.Results The recovery time of symptoms in observation group was shorter than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in serum inflammatory factors and cerebrospinal fluid inflammatory factors be-tween the two groups before treatment(both P>0.05).After treatment,the serum inflammatory factors and cerebrospi-nal fluid inflammatory factors in the observation group were better than those in the control group,and the differences were statistically significant(both P<0.05).The incidence of adverse reactions in the observation group was 2.22%,lower than that in the control group(13.33%),and the difference was statistically significant(x2=3.873,P<0.05).The total effective rate of the observation group was 97.78%,higher than that of the control group(86.67%),and the differ-ence was statistically significant(x2=3.873,P<0.05).Conclusion The application of acyclovir combined with human immunoglobulin in the treatment of viral encephalitis in children is beneficial to promote the recovery of children,re-duce the inflammatory response of children,control the disease,repair the nerve,reduce the incidence of complica-tions,and promote the prognosis of the disease.
AcyclovirIntravenous infusion of human immunoglobulinViral encephalitis
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