Effects of rhBNP Combined with Sacubitril Valsartan Sodium on Cardiac Function and Autonomic Nervous Function in Patients with Decreased Ejection Fraction Heart Failure
Objective To study and analyze the effect of recombinant human brain natriuretic peptide(rhBNP)com-bined with sakubactril valsartan on cardiac function and autonomic nervous function in decreased ejection fraction heart failure(HFrEF)patients.Methods A total of 60 patients with HFrEF admitted to Zhangzhou Third Hospital from August 2022 to August 2023 were simple randomly selected as the study objects and divided into two groups with 30 patients in each group by random number table method.The control group was treated with sacubactril valsartan so-dium as a single drug,and the observation group was treated with rhBNP and sacubactril valsartan sodium as a com-bined drug.The drug effects of the two groups were compared.Results The total clinical effective rate in observation group(93.33%)was higher than that in control group(73.33%),and the difference was statistically significant(x2=4.320,P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in the observation group was higher than that in the control group,left ventricular diastolic posterior wall thickness(LVPWD)and left ventricular diastolic di-ameter(LVPWD)were lower than those of control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of norepinephrine(NE),angiotensin Ⅱ(AngⅡ)and aldosterone in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).There was no signifi-cant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion rhBNP combined with sacubactril valsartan sodium can improve the therapeutic effect of HFrEF patients,improve their heart function and autonomic nervous function more effectively,and it is safe and reliable.
Decreased ejection fraction heart failureRecombinant human brain natriuretic peptideSacubitril valsartan sodiumCardiac functionAutonomic function
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