Effects of Agomelatine Combined with Escitalopram Oxalate on Symptoms and Sleep Quality in Depressed Patients
Objective To study the effects of agomelatine combined with escitalopram oxalate on symptoms and sleep quality in patients with depression.Methods A total of 100 patients with depression admitted to Quanzhou Third Hos-pital from October 2022 to August 2023 were simple selected as the study objects and divided into two groups by ran-dom number table method,with 50 patients in each group.The control group was given escitalopram oxalate for treat-ment,and the observation group was given agomelatine and escitalopram oxalate for treatment.The degree of depres-sive symptoms at different treatment times,sleep quality and adverse drug reactions were compared between the two groups.Results After 4 and 8 weeks of treatment,the scores of Hamilton Depression Scale(HAMD)in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After 8 weeks of treatment,the Pittsburgh Sleep Quality Index(PSQI)scores(daytime dysfunction,hypnotic drugs,time to fall asleep,sleep duration,sleep quality,sleep efficiency,and sleep disturbance)in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(12.00%vs 8.00%)(x2=0.444,P=0.504).Conclusion The combination of agomelatine and escitalopram oxalate can more effectively reduce the symp-toms of patients with depression,improve the quality of sleep of patients,and will not cause obvious drug side reac-tions,and the safety is relatively guaranteed.
NETL
NSTL
万方数据
