甲泼尼龙联合阿奇霉素治疗肺炎支原体肺炎患儿的临床效果分析
Clinical Effect Analysis of Methylprednisolone Combined with Azithromy-cin in Treating Children with Mycoplasma Pneumoniae Pneumonia
许婷婷 1黄小萍 2王春蕊1
作者信息
- 1. 南安市中医院儿科,福建南安 362300
- 2. 南安市中医院内科,福建南安 362300
- 折叠
摘要
目的 探讨肺炎支原体肺炎患儿给予甲泼尼龙联合阿奇霉素用药的疗效.方法 回顾性选取南安市中医院于2022年12月—2023年12月收治的96例支原体肺炎患儿的临床资料,根据不同用药方案将患儿分成两组,各48例.对照组予常规对症+阿奇霉素治疗,观察组在对照组的基础上增加甲泼尼龙治疗.比较两组症状缓解时间、治疗疗效、炎症因子指标、不良反应指标.结果 观察组治疗有效率为95.83%,高于对照组的81.25%,差异有统计学意义(x2=6.095,P<0.05).观察组咳嗽、发热、肺部啰音缓解时间均短于对照组,差异有统计学意义(t=9.951、6.436、9.265,P均<0.05).治疗后,观察组C反应蛋白(C-reactive Protein,CRP)、降钙素原(Procalcitonin,PCT)降至(8.69±2.21)mg/L、(0.29±0.15)ng/mL,低于对照组的(14.15±3.56)mg/L、(0.46±0.21)ng/mL,差异有统计学意义(t=9.028、9.388,P均<0.05).结论 甲泼尼龙联合阿奇霉素治疗支原体肺炎患儿,具有缩短病程,提升疗效,改善患儿炎症反应的作用,且具较好的用药安全性.
Abstract
Objective To investigate the efficacy of methylprednisolone combined with azithromycin in children with mycoplasma pneumoniae pneumonia.Methods The clinical data of 96 children with mycoplasma pneumonia admitted to Nan'an Hospital of Traditional Chinese Medicine from December 2022 to December 2023 were retrospectively se-lected,and the children were divided into two groups according to different medication regimens-48 cases each.Con-trol group was given conventional symptomatic+azithromycin,observation group 4 was given methylprednisolone on the basis of control group.Symptom remission time,therapeutic effect,inflammatory factor index and adverse reaction index were compared between the two groups.Results The effective rate of the observation group was 95.83%,which was higher than that of the control group(81.25%),and the difference was statistically significant(x2=6.095,P<0.05).The remission time of cough,fever and pulmonary rales in the observation group was shorter than that in the control group,and the differences were statistically significant(t=9.951,6.436,9.265,all P<0.05).After treatment,observa-tion group C-reactive protein(CRP)and procalcitonin(PCT)decreased to(8.69±2.21)mg/L and(0.29±0.15)ng/mL.It was lower than that of control group(14.15±3.56)mg/L and(0.46±0.21)ng/mL,and the differences were statistically significant(t=9.028,9.388,both P<0.05).Conclusion Methylprednisolone combined with azithromycin in the treat-ment of children with Mycoplasma pneumoniae pneumonia has the effect of shortening the course of the disease,im-proving the efficacy,improving the inflammatory response of the children,and has a better drug safety.
关键词
甲泼尼龙/阿奇霉素/支原体肺炎/病程时间/C反应蛋白、降钙素原、不良反应Key words
Methylprednisolone/Azithromycin/Mycoplasma pneumonia/Duration of illness/C-reactive protein/Procalcitonin/Adverse reactions引用本文复制引用
出版年
2024
NETL
NSTL
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