Clinical Study of Intravitreal Injection of Anti-vascular Endothelial Growth Factor Drugs Combined with Laser Photocoagulation in the Treat-ment of Severe Non-proliferative Diabetic Retinopathy with Macular Edema
Objective To explore the clinical effect of intravitreal injection of anti-vascular endothelial growth factor drugs combined with laser photocoagulation in the treatment of severe non-proliferative diabetic retinopathy with macular edema.Methods 80 patients with severe non-proliferative diabetic retinopathy accompanied by macular edema in the ophthalmic outpatient department of Changshu First People's Hospital from March 2020 to March 2023 were prospective randomly selected for study.They were randomly divided into two groups with forty each according to the coin toss method.The control group was treated with full retinal laser photocoagulation,and the observation group was treated with intravitreal injection of anti-vascular endothelial growth factor and full retinal laser photocoagulation.The overall clinical effect was compared.Results The total effective rate of observation group was 95.00%,which was significantly higher than that of control group 80.00%,and the difference was statistically significant(χ2=4.114,P<0.05).The visual acuity level and macular central retinal thickness of the observation group were better than those of the control group one month,three months and six months after operation,and the differences were statistically signifi-cant(all P<0.05).There was no statistically significant difference in the incidence of postoperative complications be-tween the observation group and the control group(12.50% and 20.00% )(P>0.05).Conclusion It is a safe and effec-tive treatment for patients with severe non-proliferative diabetic retinopathy complicated with macular edema by intra-vitreal injection of anti-vascular endothelial growth factor and laser photocoagulation.
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