乙酰半胱氨酸联合沙美特罗替卡松对稳定期COPD患者血清PCT、肺功能的影响
Effect of Acetylcysteine Combined with Salmeteroticasone on Serum PCT and Lung Function in Stable COPD Patients
龚章燕 1赖莉 1严永枝 1李云英1
作者信息
- 1. 黔西南布依族苗族自治州妇幼保健院内科,贵州兴义 562400
- 折叠
摘要
目的 分析稳定期慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)患者联合应用乙酰半胱氨酸、沙美特罗替卡松治疗效果以及对血清降钙素原(Procalcitonin,PCT)、肺功能的影响.方法 单纯随机选取2021年1月—2023年11月黔西南布依族苗族自治州妇幼保健院收治的100例稳定期COPD患者为研究对象,按随机数表法分为对照组(n=50,单用沙美特罗替卡松治疗)、观察组(n=50,应用乙酰半胱氨酸联合沙美特罗替卡松治疗),比较两组治疗效率、症状消失时间、PCT水平、血清白介素水平、肺功能、不良反应发生率.结果 观察组治疗效率为90.00%,高于对照组的74.00%,差异有统计学意义(χ2=4.336,P=0.037).观察组咳嗽症状消失时间、咳痰症状消失时间、呼吸气促症状消失时间、干湿啰音消失时间均短于对照组,差异有统计学意义(P均<0.05).治疗后,观察组PCT、白细胞介素-6、白介素细胞-8水平低于对照组,差异有统计学意义(P均<0.05).治疗后,观察组肺通气量、用力肺活量、最大呼吸流量高于对照组,差异有统计学意义(P均<0.05).两组不良反应总发生率比较,差异无统计学意义(P>0.05).结论 稳定期COPD患者临床治疗过程中联合应用乙酰半胱氨酸、沙美特罗替卡松具有确切效果,能够加快症状消失,下调PCT与血清白介素表达,减轻肺功能损伤,并且未出现严重的药物不良反应,安全性高.
Abstract
Objective To analyze the effects of acetylcysteine and salmeteroticasone on serum procalcitonin(PCT)and lung function in patients with stable chronic obstructive pulmonary disease(COPD).Methods A total of 100 patients with stable COPD admitted to the Qianxian Bouyei and Miao Autonomous Prefecture Maternal and Child Health Hos-pital of from January 2021 to November 2023 were simple randomly selected as the study subjects,and were divided into control group(n=50,treated with salmeteroticasone alone)and observation group(n=50,treated with acetyl cyste-ine and salmeteroticasone combined)according to random number table method.Treatment efficiency,symptom resolu-tion time,PCT and serum interleukin level,lung function and incidence of adverse reactions were compared between the two groups.Results The treatment efficiency of observation group was 90.00%,which was higher than 74.00% of control group,and the difference was statistically significant(χ2=4.336,P=0.037).The disappearance time of cough symptom,sputum symptom,shortness of breath symptom and dry and wet rales in observation group were shorter than those in control group,and the differences were statistically significant(all P<0.05).After treatment,the level of PCT,interleukin-6 and interleukin-8 in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).After treatment,the maximum voluntary ventilation,forced vital capacity and peak expiratory flow in observation group were higher than those in control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion In the course of clinical treatment of stable COPD patients,the combination of acetylcys-teine and salmeteroticasone has a definite effect,which can accelerate the disappearance of symptoms,down-regulate the expression of PCT and serum interleukin,reduce lung function injury,and no serious adverse drug reactions,with high safety.
关键词
慢性阻塞性肺疾病/稳定期/乙酰半胱氨酸/沙美特罗替卡松/降钙素原/肺功能Key words
Chronic obstructive pulmonary disease/Stable period/Acetylcysteine/Salmeterol ticasone/Procalcitonin/Lung function引用本文复制引用
出版年
2024
NETL
NSTL
万方数据