Effectiveness and Safety of Laparoscopic Radical Gastric Cancer Surgery Versus Conventional Open Surgery for Progressive Stage Gastric Cancer
Objective To compare the effect and safety of laparoscopic radical surgery with traditional open surgery for progressive stage gastric cancer.Methods A total of 70 patients with progressive stage gastric cancer admitted to Yong'an Municipal Hospital from September 2020 to September 2023 were randomly selected as study objects and di-vided into the study group(n=35)and the control group(n=35)by random number table method.Laparoscopic radical surgery was used in the study group,and traditional open surgery was used in the control group.Perioperative indices,intestinal mucosal barrier indices[D-lactic acid(D-LAC),diamine oxidase(DAO),endotoxin(ET)],oxidative stress indices[superoxide dismutase(SOD),total antioxidant capacity(TAC),malondialdehyde(MDA)],and complications were compared between the two groups.Results The first postoperative venting and hospitalization time in the study group were shorter than those in the control group,the differences were statistically significant(t=22.300,9.293,both P<0.05),intraoperative bleeding was less,the difference was statistically significant(t=26.957,P<0.05),and postop-erative DAO,D-LAC,and ET were elevated in the two groups,but they in the study group were lower than those in the control group,the differences were statistically significant(t=4.079,4.003,5.302,all P<0.05).Postoperatively,TAC and SOD decreased and MDA increased in both groups,but TAC and SOD in the study group were higher than those in the control group and MDA was lower,the differences were statistically significant(t=2.082,2.518,5.401,all P<0.05)The incidence of complications in the study group(2.86% )was lower than that in the control group(22.86% ),the difference was statistically significant(χ2=4.590,P<0.05).Conclusion The use of laparoscopic radical surgical treatment for patients with progressive stage gastric cancer can reduce the amount of intraoperative bleeding,shorten the postoperative recovery and hospitalization time,protect the intestinal mucosal barrier function,and reduce the oxi-dative stress response,as well as reduce the incidence of postoperative complications.
Laparoscopic radical surgeryProgressive stage gastric cancerTraditional open surgerySafety
NETL
NSTL
万方数据
