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阿比多尔联合奥司他韦治疗对流感患者的临床效果分析

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目的 探讨阿比多尔联合奥司他韦治疗流感的临床效果.方法 回顾性选取2022年7月—2023年6月福建医科大学附属福州市第一总医院收治的82例流行性感冒患者的临床资料,按照治疗方式不同分为对照组(n=41)和研究组(n=41).对照组采用阿比多尔,研究组采用阿比多尔与奥司他韦联用.对比两组总有效率、不良反应发生情况,以及治疗前后血清炎性因子水平和症状评分.结果 研究组总有效率为97.56%,高于对照组的82.93%,差异有统计学意义(χ2=4.987,P=0.026).研究组与对照组不良反应总发生率分别为4.88%和2.44%,差异无统计学意义(χ2=0.346,P=0.556).治疗后,研究组的血清C反应蛋白、白细胞介素-6、降钙素原均低于对照组,差异有统计学意义(P均<0.001).治疗后,研究组发热、咳嗽、乏力等症状的评分均低于对照组,差异有统计学意义(P均<0.001).结论 在治疗流行性感冒患者时,阿比多尔与奥司他韦联合应用可增强临床疗效,促使症状有效缓解,使炎症反应得以减轻,且联合用药的安全性良好.
Effect of Abidol Combined with Oseltamivir on Fever in Patients with In-fluenza
Objective To explore the improvement effect of abidol combined with oseltamivir on influenza.Methods The clinical data of 82 patients with influenza admitted to Fuzhou First General Hospital Affiliated to Fujian Medical University from July 2022 to June 2023 were retrospectively selected.According to different treatment methods,they were divided into control group(n=41)and study group(n=41).The control group was treated with abidol,and the study group was treated with abidol combined with oseltamivir.The total effective rate,adverse reactions,serum in-flammatory factor levels and symptom scores of the two groups before and after treatment were compared.Results The total effective rate of the study group was 97.56%,which was higher than 82.93% of the control group,and the differ-ence was statistically significant(χ2=4.987,P=0.026).The total incidence of adverse reactions in the study group and the control group was 4.88% and 2.44%,respectively,and the difference was not statistically significant(χ2=0.346,P=0.556).After treatment,the serum C-reactive protein,interleukin-6 and procalcitonin in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.001).After treatment,the scores of fever,cough and fatigue in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.001).Conclusion In the treatment of influenza patients,the combination of abi-dol and oseltamivir can enhance clinical efficacy,promote effective relief of symptoms,reduce inflammation,with good safety.

InfluenzaAbidolOseltamivir

张龙升、林建英、黄姗姗

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福建医科大学附属福州市第一总医院感染性疾病科,福建福州 350000

流行性感冒 阿比多尔 奥司他韦

2024

中外医疗
卫生部医院管理研究所 二十一世纪联合创新医药科学研究院

中外医疗

影响因子:0.909
ISSN:1674-0742
年,卷(期):2024.43(14)