Effects of Aripiprazole Combined with Paliperidone Treatment on Cogni-tive Function and Neurotrophic Factor in Patients with Schizophrenia
Objective To analyze the effect of the combined treatment with aripiprazole and paliperidone in patients with schizophrenia.Methods 106 patients with schizophrenia seen at Nanjing Jiangning District Second People's Hos-pital from January 2021 to June 2023 were conveniently selected as the study objects,and divided into a control group and an observation group of 53 cases each according to the random number table method.The control group was treated with paliperidone,and the observation group was treated with aripiprazole combined with paliperidone.Com-pare the treatment effect,neurotrophic factor,cognitive function score and incidence of adverse reactions between the two groups.Results The total effective rate of treatment in the observation group(94.34%)was lower than that in the control group,and the difference was statistically significant(x2=4.296,P<0.05).The levels of all neurotrophic factors in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The cognitive function score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(x2=4.970,P<0.05).Conclusion For patients with schizophrenia,simultaneous treatment with paliperidone and aripiprazole has certain advantages,which can maximize the improvement of patients'neurological function and cognitive function,and the incidence of adverse events is lower.
NETL
NSTL
万方数据
