Exploration of the Effect of Sacubitril Valsartan Combined with Lyophi-lized Recombinant Human Cerebral Natriuretic Peptide in the Treatment of Heart Failure
Objective To explore the effect of the combined application of sacubitril valsartan and lyophilized recombi-nant human brain natriuretic peptide in the treatment of heart failure patients.Methods The clinical data of 120 heart failure patients treated in Youxi County General Hospital from October 2021 to November 2023 were retrospectively selected and grouped according to different treatment modalities.Control group(60 cases,sacubitril valsartan treat-ment),observation group(60 cases,sacubitril valsartan combined with lyophilized recombinant human cerebral natri-uretic peptide treatment).Comparison of cardiac function level,serum index level,therapeutic efficacy,and incidence of adverse reactions between the two groups before and after treatment.Results Before treatment,there was no statisti-cally significant difference in cardiac function between the two groups(P>0.05);after treatment,the observation group's cardiac function improvement effect was better than that of the control group,and the difference was statisti-cally significant(P<0.05).There was no statistically significant difference in the comparison of serum indexe between the groups before treatment(P>0.05);and after treatment,the serum indexe of the observation group was better than that of the control group,the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group(98.33%)was higher than that in the control group(86.67%),and the difference was statistically sig-nificant(x2=5.886,P=0.015).The difference in the incidence of adverse reactions between the two groups was not sta-tistically significant(x2=0.697,P=0.404).Conclusion In the treatment of heart failure patients,the use of sacubitril valsartan combined with lyophilized recombinant human cerebral natriuretic peptide can improve their cardiac func-tion,serum index levels,and achieve significant efficacy.
Sacubitril valsartanLyophilized recombinant human brain natriuretic peptideHeart failureCombined therapyCardiac function
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