Clinical Effect of Levocarnitine Combined with Hemodialysis in the Treat-ment of Elderly Patients with Chronic Renal Failure
Objective To explore the clinical effect of levocarnitine combined with hemodialysis treatment in elderly patients with chronic renal failure(CRF).Methods Ninety cases of elderly CRF patients admitted to Gaotang County Hospital of Traditional Chinese Medicine from September 2021 to August 2023 were conveniently selected for the study,and were divided into the control group and the study group by random number table method,with 45 cases in each group.The control group was given hemodialysis treatment,and the study group was given levocarnitine com-bined with hemodialysis treatment.Compare the clinical efficacy,renal function[blood urea nitrogen(BUN),serum creatinine(Scr),endogenous creatinine clearance rate(Ccr),cystatin C(CysC),estimated glomerular filtration rate(eGFR)],inflammatory factor levels[tumor necrosis factor-α(TNF-α),C-reaction protein(CRP),interleukin-8(IL-8)],and toxin clearance rate of the two groups.Results The total effective rate of treatment in the study group was 91.11%,which was higher than that of 73.33%in the control group,and the difference was statistically significant(χ2=4.865,P<0.05).Ccr and eGFR increased and BUN,Scr and CysC decreased in both groups after treatment,and Ccr and eGFR were higher and BUN,Scr and CysC were lower in the study group than those in the control group,and the differences were statistically significant(all P<0.05).The levels of TNF-α,CRP,and IL-8 decreased in both groups after treatment,and they were lower in the study group than those in the control group,the differences were statisti-cally significant(all P<0.05).Blood potassium,blood phosphorus,and parathyroid hormone clearance were higher in the study group than in the control group,and the differences were statistically significant(all P<0.05).Conclusion Levocarnitine combined with hemodialysis for the treatment of elderly CRF patients can enhance the clinical efficacy,improve renal function,alleviate the inflammatory response,and promote the improvement of toxin clearance.
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