Efficacy Analysis of Sofosbuvir and Velpatasvir in the Treatment of Geno-type 2a Hepatitis
Objective To explore the clinical efficacy of sofosbuvir and velpatasvir in the treatment of patients with genotype 2a chronic hepatitis C(CHC)combined with type 2 diabetes mellitus(T2DM).Methods 162 patients with genotype 2a CHC combined with T2DM admitted to Zhangye People's Hospital Affiliated to Hexi College from Janu-ary 2020 to December 2022 were conveniently selected for the study,and were divided into the control group and the observation group,each with 81 cases,by random number table method.The control group was given ribavirin+inter-feron treatment,and the observation group was added sofosbuvir and velpatasvir treatment on the basis of the control group.Compare the clinical efficacy,viral response rate,liver function indexes,inflammatory factors,and treatment safety of the two groups.Results The total effective rate of treatment the observation group was 92.59%,which was higher than that of the control group of 79.01%,and the difference was statistically significant(χ2=6.131,P<0.05).The early virological response rate,virological response rate at the end of treatment,viral response rate 24 weeks after drug cessation and viral response rate 48 weeks after drug cessation of patients in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the liver function indexes of the observation group were lower than those of the control group,and the differences were statisti-cally significant(all P<0.05).After treatment,the levels of inflammatory factors in the observation group were all lower than those in the control group,and the differences were statistically significant(all P<0.05).Comparing the occur-rence of adverse reactions in the two groups,the difference was not statistically significant(P>0.05).Conclusion Sofos-buvir and velpatasvir is effective in the treatment of patients with genotype 2a CHC combined with T2DM,which can improve the viral response rate of the patients,improve the liver function indexes,inhibit the level of inflammatory fac-tors,and has good safety.
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