门冬胰岛素30联合二甲双胍恩格列净对2型糖尿病患者糖脂代谢的影响
Effect of Insulin Aspartate 30 Combined with Metformin Empagliflozin on Glycolipid Metabolism in Type 2 Diabetic Patients
李飞 1张新新1
作者信息
- 1. 淮安工业园区人民医院内分泌科,江苏淮安 223003
- 折叠
摘要
目的 分析门冬胰岛素30联合二甲双胍恩格列净治疗2型糖尿病(Type 2 Diabetes Mellitus,T2DM)的效果.方法 方便选取淮安工业园区人民医院于2021年9月—2023年9月收治的94例T2DM患者为研究对象,按随机数表法分成两组,各47例.对照组行二甲双胍恩格列净治疗,观察组加用门冬胰岛素30治疗.比较两组临床疗效.结果 观察组治疗总有效率为93.62%,高于对照组的78.72%,差异有统计学意义(χ2=4.374,P=0.037).治疗后,观察组血糖指标、血脂指标、胰岛功能指标优于对照组,差异有统计学意义(P均<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论 门冬胰岛素30联合二甲双胍恩格列净可改善T2DM患者的糖脂代谢,减轻胰岛功能障碍,且无严重不良反应.
Abstract
Objective To analyze the effect of insulin aspartate 30 combined with metformin and empagliflozin on pa-tients with type 2 diabetes mellitus(T2DM).Methods A total of ninety-four T2DM patients admitted to Huai'an In-dustrial Park People's Hospital from September 2021 to September 2023 were conveniently selected as the study ob-jects,and were divided into two groups according to random number table method,with forty-seven cases in each group.The control group was treated with metformin and empagliflozin,and the observation group was treated with in-sulin aspartate 30.The clinical efficacy of the two groups was compared.Results The total effective rate of the observa-tion group was 93.62%,which was higher than 78.72%of the control group,and the difference was statistically signifi-cant(χ2=4.374,P=0.037).After treatment,the blood glucose index,blood lipid index and islet function index of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Insulin aspartate 30 combined with metformin empagliflozin can improve glucose and lipid me-tabolism and alleviate islet dysfunction in T2DM patients without serious adverse reactions.
关键词
2型糖尿病/血糖/血脂/不良反应/糖脂代谢Key words
Type 2 diabetes/Blood glucose/Blood lipid/Adverse reactions/Glycolipid metabolism引用本文复制引用
出版年
2024
NETL
NSTL
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