Objective To investigate the analgesic effect of acetaminophen mannitol injection after knee joint replace-ment.Methods A total of one hundred and twenty patients admitted to undergoing total knee replacement in Jining Second People's Hospital from September 2022 to June 2023 were randomly selected as the study objects,all of whom were single-knee lesions.They were divided into two groups with sixty cases in each group according to double-blind random number sampling.The observation group received acetaminophen mannitol analgesia combined with sufentanil analgesia.Sufentanil analgesia was used in control group.The analgesic effect of the two groups was compared.Results The pain visual pattern scores of the observation group at rest and activity(kneeling to 45°)at 4,8,12 and 24 h after surgery were lower than those of the control group,the differences were statistically significant(all P<0.05).The dosage of sufentanil in the observation group was lower than that in the control group during and with in 24 h after operation,and the differences were statistically significant(both P<0.05).The total incidence of ad-verse reactions in the observation group was 3.33%,lower than that in the control group(15.00%),and the difference was statistically significant(χ2=4.904,P<0.05).Conclusion Acetaminophen mannitol analgesia combined with sufent-anil analgesia can reduce the pain of patients,reduce the use of opioids,and fewer adverse reactions.
维普
万方数据