Objective To analyze the effectiveness of less invasive surfactant administration(LISA)combined with transnasal continuous positive airway pressure(NCPAP)for neonatal respiratory distress syndrome.Methods A total of eighty children with neonatal respiratory distress syndrome in the pediatrics department of Jining First People's Hospi-tal from April 2021 to June 2023 were randomly selected as the study objects and divided into analysis group and ref-erence group by drawing lots,with forty cases in each group.Analysis group was treated with LISA technology com-bined with NCPAP,and reference group was treated with tracheal intubation and pulmonary surfactant perfusion.The therapeutic effect of the two groups was compared.Results After treatment,the effective rate of the analysis group(95.00%)was higher than that of the reference group(75.00%),the difference was statistically significant(χ2=6.274,P=0.012).After treatment,the mechanical ventilation time,hospitalization time and oxygen inhalation time in the analy-sis group were shorter than those in the reference group,and the differences were statistically significant(all P<0.05).After treatment,the level of advanced oxidation protein products(AOPPs)in analysis group was lower than that in ref-erence group,and the difference was statistically significant(P<0.05).After treatment,blood gas indexes and pulmo-nary circulation function indexes in analysis group were better than those in reference group,and the differences were statistically significant(both P<0.05).The incidence of adverse reactions in analysis group was lower than that in refer-ence group,and the difference was statistically significant(P<0.05).Conclusion LISA technology combined with NCPAP in the treatment of neonatal respiratory distress syndrome is beneficial to improve the blood oxygen index of newborns,improve the pulmonary functional circulation,shorten the mechanical ventilation time of newborns,and re-duce the occurrence of adverse reactions.
LISA technologyNeonatal respiratory distress syndromeNCPAP therapyAdverse reaction
维普
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