Study on the Clinical Value of Application of Meropenem Therapy in Pedi-atric Purulent Meningitis in Children
Objective To explore the effect of meropenem application in the treatment of purulent meningitis in chil-dren.Methods 62 cases of pediatric purulent meningitis children admitted to Lianyungang Maternal and Child Health Hospital from January 2018 to February 2024 were conveniently selected as the study object,and they were divided into two groups based on the different medications used,with 31 cases in each group.The control group was treated with ceftriaxone+amoxicillin sulbactam,and the observation group was treated with injectable meropenem on the ba-sis of the control group,comparing the recovery,inflammatory response,therapeutic efficiency and the occurrence of adverse reactions in the two groups.Results In the observation group,the recovery time of body temperature,the re-duction time of intracranial pressure,the disappearance time of meningeal irritation signs,and the return time of med-ullary fluid to normal in the observation group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the inflammatory factor of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 96.77%,which was higher than 74.19%in the control group,and the difference was sta-tistically significant(χ2=4.679,P=0.031).Comparing the incidence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion The addition of meropenem for the treatment of pediat-ric purulent meningitis can improve the clinical therapeutic efficacy,which is important for accelerating the speed of recovery and reducing the level of inflammation,and also ensures the safety of children medication.
Purulent meningitis in childrenMeropenemTherapeutic effectMedication safety
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