Analysis of Clinical Effect of Low Tidal Volume Lung Protective Ventila-tion on Respiratory Failure Caused By Acute Organophosphorus Pesticide Poisoning
Objective To explore the clinical effect of lung protective ventilation with low tidal volume on patients with respiratory failure caused by acute organophosphorus pesticide poisoning(AOPP).Methods The clinical data of 60 patients with AOPP-induced respiratory failure treated in Wuping County Hospital in Longyan City from February 2021 to September 2023 were retrospectively selected and divided into two groups according to different treatment methods,with 30 cases in each group.The control group was treated with conventional mechanical ventilation,and the observation group was treated with low tidal volume lung protective ventilation.The indexes of blood gas analysis,re-habilitation effect,oxidative stress and safety were compared between the two groups.Results After treatment,the re-covery time of observation group was shorter than that of control group,the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in blood gas analysis index and oxidative stress level between two groups(both P>0.05);after treatment,the arterial blood oxygen partial pressure,superoxide dis-mutase,oxygen saturation and fixed glutathione level in observation group were higher than those in control group,while the arterial blood carbon dioxide partial pressure and malondialdehyde indexes were lower than those in control group,the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the observation group was 6.67%,compared with 16.67%in the control group,the difference was not statistically significant(χ2=0.647,P=0.421).Conclusion Low tidal volume lung protective ventilation in the treatment of acute organophosphorus pesticide poisoning caused by respiratory failure patients can effectively alleviate oxidative stress damage,adjust the level of blood gas analysis index,and promote the recovery of patients.
万方数据
维普
