Objective To analyze the effect of nasal high flow oxygen therapy in emergency patients with acute respira-tory distress and hypoxemia.Methods A total of 91 patients with acute dyspnea and hypoxemia admitted to Xinyi People's Hospital from October 2022 to December 2023 were conveniently selected as the research objects and di-vided into study group(n=45)and control group(n=46)by random number table method.The control group was treated with routine oxygen therapy,and the study group was treated with nasal high flow oxygen therapy.Both groups were treated for 1 h.The physiological indexes(heart rate,respiratory rate,mean arterial pressure),blood gas indexes(arterial partial pressure of carbon dioxide,blood oxygen saturation)and prognostic indexes(intubation rate)were com-pared between the two groups.Results Before and after treatment,there was no significant difference in the level of physiological indexes between the two groups(P>0.05).After treatment,the levels of physiological indexes in the two groups were lower than those before treatment,and the differences were statistically significant(both P<0.05).Before treatment,there was no significant difference in blood gas indexes between the two groups(P>0.05).After treatment,the arterial partial pressure of carbon dioxide in the study group was(38.71±3.21)mmHg,and the blood oxygen satura-tion was(91.47±6.27)%,which were better than those in the control group,the differences were statistically significant(t=5.708,2.709,both P<0.05).The intubation rate of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Nasal high-flow oxygen therapy for patients with acute dyspnea and hypoxemia can improve the blood gas index level and help to reduce the intubation rate,thereby reducing the body injury of patients.