Clinical Effect of Budesonide Combined with Ambroxol Hydrochloride Nebulised Inhalation for Acute Exacerbation of Chronic Obstructive Pul-monary Disease
Objective To explore the efficacy of budesonide combined with ambroxol hydrochloride in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 64 patients with acute exac-erbation of COPD admitted to Lianshui County Hospital of Traditional Chinese Medicine from March 2023 to March 2024 were conveniently selected as the research objects,and they were divided into two groups by random number table method,with 32 cases in each group.The control group was given budesonide atomization inhalation,and the ob-servation group was combined with ambroxol hydrochloride atomization inhalation on the basis of the control group.The clinical effects,lung function,inflammatory factors and adverse reactions were compared between the two groups.Result The total effective rate of the observation group(96.88%)was higher than that of the control group(81.25%),and the difference was statistically significant(χ2=4.010,P<0.05).After treatment,the levels of lung function indexes in the two groups increased significantly,and those in the observation group were higher than the control group,the differences were statistically significant(all P<0.05).The levels of inflammatory factors in the two groups were signifi-cantly reduced,and the observation group was lower than the control group,the differences were statistically signifi-cant(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion The combination of budesonide and ambroxol hydro-chloride atomization in the treatment of the acute exacerbation of COPD is very effective,which can improve lung function,reduce inflammatory factors and have fewer adverse reactions.
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维普
