首页|特布他林与布地奈德序贯用药对支气管哮喘患儿肺功能及机体免疫状况的影响分析

特布他林与布地奈德序贯用药对支气管哮喘患儿肺功能及机体免疫状况的影响分析

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目的 探究特布他林与布地奈德序贯用药对支气管哮喘患儿肺功能及机体免疫状况的影响.方法 随机选取2021年8月—2024年1月南安市医院收治的80例支气管哮喘患儿为研究对象,依照随机数字表法分为两组,各40例.两组均予以特布他林及布地奈德联合治疗,其中对照组采取雾化方式给药,观察组采取序贯用药方式给药,对比两组的疗效、哮喘症状、肺功能以及机体免疫情况.结果 观察组用药总有效率(97.50%)高于对照组(80.00%),差异有统计学意义(χ2=4.507,P=0.033).治疗后,观察组哮喘控制简易方案中的日间及夜间得分均低于对照组,差异有统计学意义(P均<0.05).治疗后,观察组达峰时间比及容积比均大于对照组,差异有统计学意义(P均<0.05).治疗后,观察组机体免疫指标优于对照组,差异有统计学意义(P<0.05).结论 对支气管哮喘患儿施以特布他林及布地奈德序贯用药有更理想的疗效,可更有效控制哮喘发作,改善患儿的肺功能及机体免疫状况.
Analysis of the Effect of Sequential Administration of Terbutaline and Budesonide on Pulmonary Function and Immune Status in Children with Bronchial Asthma
Objective To investigate the effects of sequential administration of terbutaline and budesonide on lung function and immune status in children with bronchial asthma.Methods A total of 80 children with bronchial asthma admitted to Nan'an Hospital from August 2021 to January 2024 were randomly selected as study objects and divided into two groups according to the random number table method,with 40 cases in each group.Both groups were treated with terbutaline and budesonide.The control group was administered by atomization,and the observation group was administered by sequential administration.The effective rate of medication,the degree of asthma symptoms,lung func-tion and body immunity were compared between the two groups.Results The total effective rate of the observation group(97.50%)was higher than that of the control group(80.00%),and the difference was statistically significant(χ2=4.507,P=0.033).After treatment,the daytime and nighttime scores of the simple asthma control program in the obser-vation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the peak time ratio and volume ratio of the observation group were higher than those of the con-trol group,and the differences were statistically significant(both P<0.05).After treatment,the immune index of the ob-servation group was better than that of the control group,and the difference was statistically significant(P<0.05).Con-clusion The sequential use of terbutaline and budesonide in children with bronchial asthma has more ideal curative ef-fect,can more effectively control the attack of asthma,and improve the lung function and immune status of children.

Bronchial asthmaTerbutalineBudesonidePulmonary functionImmune status

许晓东、陈锦栋、陈茵治

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南安市医院儿科,福建 泉州 362300

支气管哮喘 特布他林 布地奈德 肺功能 机体免疫状况

2024

中外医疗
卫生部医院管理研究所 二十一世纪联合创新医药科学研究院

中外医疗

影响因子:0.909
ISSN:1674-0742
年,卷(期):2024.43(19)
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