Analysis of the Clinical Efficacy and Safety of Mannitol Combined with So-dium Aescinate in the Treatment of Traumatic Brain Edema
Objective To investigate the clinical effect and safety of mannitol combined with sodium aescinate in the treatment of traumatic brain edema.Methods A total of 92 patients with traumatic cerebral edema admitted to the Songtao Miao Autonomous County Ethnic Traditional Chinese Medicine Hospital from December 2020 to December 2023 were conveniently selected as the study subjects.According to different treatment methods,they were divided into control group and observation group,with 46 cases in each group.The control group was treated with mannitol on the basis of conventional treatment,while the observation group was treated with sodium aescinate on the basis of con-trol group.The intervention effect of cerebral edema,degree of neurological impairment,coma index,neurological function and safety of the two groups were compared.Results After treatment,the cerebral edema volume in the obser-vation group was smaller than that in the control group,and the effective rate was greater than that in the control group,the differences were statistically significant(t=23.122,χ2=3.903,both P<0.05).The Modified Edinburgh-Scandinavianstroke Scale score of the observation group was(14.79±2.02)points,lower than that of the control group(17.51±2.38)points,and the difference was statistically significant(t=5.910,P<0.05).The score of Glasgow Coma Scale in the observation group was higher than that in the control group,and the score of National Institutes of Health Stroke Scale was lower than that in the control group,the differences were statistically significant(t=7.363,7.631,both P<0.05).During the treatment of the two groups of patients,no significant adverse reactions were observed.Con-clusion Mannitol combined with sodium aesculin in the treatment of traumatic brain edema showed good efficacy and safety,especially in reducing the volume of brain edema and improving nerve function significantly superior to the tra-ditional treatment of mannitol alone.
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