首页|失代偿期肝硬化TIPS术后轻微型肝性脑病的中医证型及危险因素分析

失代偿期肝硬化TIPS术后轻微型肝性脑病的中医证型及危险因素分析

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目的 探析失代偿期肝硬化行经颈静脉肝内门体静脉分流术(Transjugular Intrahepatic Portosystemic Shunt,TIPS)术后轻微型肝性脑病(Minimal Hepatic Encephopathy,MHE)的危险因素.方法 回顾性选取2022年7月—2024年3月间福建医科大学孟超肝胆医院收治的70例失代偿期肝硬化行TIPS术的患者的临床资料,收集其性别、年龄、脾切除术史、是否合并腹水、Child-Pugh评分、糖尿病史、高血压史以及营养风险等信息,分析MHE发病率以及危险因素.结果 经数字连接试验及数字符号试验测定,70例患者中27例发生MHE,MHE发病率为38.57%.在有无脾切除术史、有无合并腹水、Child-Pugh评分、有无营养风险方面,MHE组和非MHE组组间对比,差异有统计学意义(P均<0.05).多因素Logistic回归分析显示,有脾切除术史、合并腹水、Child-Pugh评分B或C级以及有营养风险是失代偿期肝硬化患者TIPS术后MHE的相关发病危险因素(OR=1.088、1.107、3.121、1.007,P均<0.05).结论 失代偿期肝硬化TIPS术后轻微型肝性脑病发病率较高,有脾切除术史、有合并腹水、Child-Pugh评分B或C级以及有营养风险是MHE的发病危险因素.
Analysis of Traditional Chinese Medicine Syndromes and Risk Factors of Minimal Hepatic Encephalopathy after TIPS in Decompensated Cirrhosis
Objective To explore the risk factors of minimal hepatic encephalopathy(MHE)after decompensate cirrho-sis transjugular intrahepatic portosystemic shunt(TIPS)surgery.Methods The clinical data of 70 patients with decom-pensated cirrhosis who underwent TIPS in Mengchao Hepatobiliary Hospital of Fujian Medical University from July 2022 to March 2024 were retrospectively selected.Their gender,age,history of splenectomy,ascites,Child-Pugh score,history of diabetes,history of hypertension and nutritional risk were collected to analyze the incidence and risk factors of MHE.Results According to Number Connection Test-A and Digit Symbol Test,27 of 70 patients had MHE,and the incidence of MHE was 38.57%.There were significant differences between the MHE group and the non-MHE group in the history of splenectomy,ascites,Child-Pugh score and nutritional risk(all P<0.05).Multivariate Logistic regression analysis showed that the history of splenectomy,ascites,Child-Pugh score B or C and nutritional risk were risk factors for MHE after TIPS in patients with decompensated cirrhosis(OR=1.088,1.107,3.121,1.007,all P<0.05).Conclusion The incidence of minimal hepatic encephalopathy after TIPS in decompensated cirrhosis is high.History of splenectomy,ascites,Child-Pugh score B or C and nutritional risk are risk factors for MHE.

Decompensated cirrhosisTransjugular intrahepatic portosystemic shuntMinimal hepatic encephalopathyRisk factors

林安阳、陈玮、周文、朱灯、吴仕明、郭武华、洪美珠

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福建医科大学孟超肝胆医院中西医结合肝病科,福建 福州 350000

福建医科大学孟超肝胆医院介入科,福建 福州 350000

失代偿期肝硬化 经颈静脉肝门体静脉分流术 轻微型肝性脑病 危险因素

福建中医药大学校管科研课

XB2022016

2024

中外医疗
卫生部医院管理研究所 二十一世纪联合创新医药科学研究院

中外医疗

影响因子:0.909
ISSN:1674-0742
年,卷(期):2024.43(20)