Effect of Phloroglucinol Combined with Ritodrine Hydrochloride in the Treatment of Threatened Abortion Patients with Pregnancy More Than 20 Weeks
Objective To investigate the effect of phloroglucinol combined with ritodrine hydrochloride on fetal preser-vation in patients with threatened abortion over 20 weeks of pregnancy.Methods A total of 120 patients with threat-ened abortion admitted to Xinxian People's Hospital of Shandong Province from November 2021 to December 2023 were randomly selected as the study subjects.According to different treatment methods,they were divided into single group and combined group,with 60 cases in each group.The single group was treated with phloroglucinol,while the combined group was treated with ritodrine hydrochloride.After 7 days of continuous treatment,symptom resolution time,the levels of sex hormone indexes[progesterone(P),estradiol(E2)]and the levels of inflammatory factor indexes[interleukin-10(IL-10),interleukin-6(IL-6),interleukin-17(IL-17)]and adverse drug reactions were compared be-tween patients in two groups.Results The contraction disappearance time(2.27±0.79)h and the stop time of vaginal bleeding(11.36±1.43)h in the combined group were shorter than those in the single group,and the differences were statistically significant(t=39.131,24.175,both P<0.05).After 7 days of treatment,P,E2 and β-HCG in patients in two groups were higher than before treatment,P(73.88±21.36)mmol/L,E2(632.76±83.97)pg/mL and β-HCG[(5 985.35±154.87)U/L]in combination group were higher than those in single group and the differences were statisti-cally significant(all P<0.05).After 7 days of treatment,the levels of IL-10 was increased in patients in both groups,while the levels of IL-6 and IL-17 were decreased,the levels of IL-10(153.43±12.35)pg/mL,IL-6(12.36±1.32)pg/mL and IL-17(12.32±4.13)pg/mL in the combined group were superior to those in the single group and the differences were statistically significant(all P<0.05).There was no significant difference in the total rate of adverse reactions be-tween patients in two groups(P>0.05).Conclusion The application of phloroglucinol combined with ritodrine hydro-chloride in the treatment of fetal preservation in patients with threatened abortion at more than 20 weeks of pregnancy can improve the effect of fetal preservation,increase sex hormones,and improve the inflammation index of the body,with good safety.
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