Comparative Analysis of the Effects of Rifapentine-containing and Rifampicin-Containing Anti-tuberculosis Regimens on Newly Diagnosed Pulmonary Tuberculosis and Their Effects on Liver Function
Objective To analyze and compare the efficacy of rifapentine-containing and rifampin-containing anti-tuberculosis regimens in patients with newly diagnosed pulmonary tuberculosis.Methods The clinical data of 92 pa-tients with newly diagnosed pulmonary tuberculosis admitted to Fuzhou Tuberculosis Prevention and Control Hospital from September 2021 to September 2023 were retrospectively selected and divided into control group and observation group according to different treatment methods,with 46 cases in each group.The control group was treated with rifampicin-containing anti-tuberculosis regimen,and the observation group was treated with rifapentine-containing anti-tuberculosis regimen.The sputum negative conversion rate,clinical efficacy,inflammatory factor level,liver func-tion and adverse reactions were compared between patients in two groups.Results The sputum negative conversion rate of the observation group was 95.65%,the total effective rate of treatment was 97.83%,which were higher than 82.61%and 82.61%of the control group,and the incidence of adverse reactions was 6.52%,which was lower than 21.74%of the control group,the differences were statistically significant(χ2=4.039,4.434,4.389,P=0.044,0.035,0.036).After treatment,the levels of inflammatory factors and liver function indexes in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion The rifapentine-containing anti-tuberculosis regimen can accelerate the sputum negative conversion of newly diagnosed pulmonary tuberculosis patients,reduce inflammation and liver function damage,and have fewer adverse reactions,which is worthy of clinical reference.
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