目的 探讨慢性乙型肝炎(Chronic Hepatitis B Virus,CHB)患者采用聚乙二醇干扰素α-2b(Peg Inter-feron α-2b,Peg-IFN-α-2b)联合核苷(酸)类似物(Nucleoside Analogues and Nucleotide Analogues,NAs)治疗对乙肝表面抗原(Hepatitis B Surface Antigen,HBsAg)清除率的影响.方法 回顾性选取2019年6月—2022年6月厦门大学附属第一医院收治的148例CHB患者的临床资料,按照治疗方法的不同分成研究组(n=74)与对照组(n=74),对照组采用NAs治疗,研究组采用Peg-IFN-α-2b联合NAs治疗,比较两组患者HBsAg血清转阴率与转换率、乙肝病毒脱氧核糖核酸含量、肝功能指标、血清炎症因子水平.结果 治疗12个月后,研究组HBsAg血清转阴率与转换率分别为35.14%、27.03%均高于对照组,差异有统计学意义(χ2=17.995、17.299,P均<0.05).治疗12个月后,两组患者乙肝病毒脱氧核糖核酸含量均下降,且研究组低于对照组,差异有统计学意义(P均<0.05).两组患者谷草转氨酶、谷丙转氨酶均下降,且研究组低于对照组,差异有统计学意义(t=7.713、2.089,P均<0.05).两组患者白细胞介素-6、肿瘤坏死因子-α水平均下降,且研究组低于对照组,差异有统计学意义(t=10.820、7.032,P均<0.05).结论 CHB患者采用Peg-IFN-α-2b联合NAs治疗,可提高HBsAg血清转阴率与转换率,降低HBV-DNA含量,降低肝功能指标,降低血清炎症因子指标.
Effect Analysis of Pegylated Interferon α-2b Combined with Nucleoside Analogues and Nucleotide Analogues on HBsAg Clearance Rate in Patients with Chronic Hepatitis B
Objective To explore the effect of peg interferon α-2b(Peg-IFN-α-2b)and nucleoside analogues and nucleotide analogues(NAs)in chronic hepatitis B virus(CHB)patients on hepatitis B surface antigen(HBsAg)clear-ance rate.Methods The clinical data of 148 CHB patients admitted to the First Affiliated Hospital of Xiamen Univer-sity from June 2019 to June 2022 were retrospectively selected and divided into study group(n=74)and control group(n=74)according to different treatment methods.The control group was treated with NAs,and the study group was treated with Peg-IFN-α-2b combined with NAs.The HBsAg serum negative conversion rate and conversion rate,hepatitis B virus deoxyribonucleic acid content,liver function index and the level of serum inflammatory factors were compared between the two groups.Results After 12 months of treatment,the serum negative conversion rate and con-version rate of HBsAg in the study group were 35.14%and 27.03%,respectively,higher than those in the control group,and the differences were statistically significant(χ2=17.995,17.299,both P<0.05).After 12 months of treat-ment,the content of hepatitis B virus deoxyribonucleic acid in the two groups decreased,and that in the study group was lower than the control group,the difference was statistically significant(P<0.05).The levels of aspartate amino-transferase and alanine aminotransferase in the two groups decreased,and those in the study group were lower than those in the control group,the differences were statistically significant(t=7.713,2.089,both P<0.05).The levels of in-terleukin-6 and tumor necrosis factor-α in the two groups decreased,and those in the study group were lower than the control group,the differences were statistically significant(t=10.820,7.579,both P<0.05).Conclusion Patients with CHB treated with Peg IFN-α-2b and NAs,which can increase the seroconversion rate and conversion rate of HBsAg,reduce HBV-DNA content,and lower serum inflammatory factor indicators.
Chronic hepatitis BPolyethylene glycol interferon α-2bNucleoside analogues and nucleotide analoguesHepatitis B surface antigen
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