Application of Methylprednisolone Combined with Azithromycin in Chil-dren with Severe Mycoplasma Pneumoniae Pneumonia and Its Effect on Body Inflammation
Objective To investigate the application of methylprednisolone combined with azithromycin in children with severe Mycoplasma pneumoniae pneumonia(MPP)and its effect on inflammation.Methods A total of 50 children with severe MPP admitted to the Second Hospital of Sanming City from February 2021 to February 2024 were simple randomly selected as the research objects,and they were divided into two groups according to the random number table method,with 25 cases in each group.The control group was treated with azithromycin alone,and the observation group was treated with intravenous infusion of methylprednisolone on the basis of the control group.The medication ef-fect,pneumonia symptom control time,body inflammation status and incidence of adverse drug reactions in the two groups were compared.Results The total effective rate of the observation group(100.00%)was higher than that of the control group(76.00%),and the difference was statistically significant(χ2=4.734,P=0.029).The control time of pneu-monia symptoms(fever,cough and pulmonary rales)in the observation group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the level of inflammatory indexes(procalcitonin,C-reactive protein and lactate dehydrogenase)in the observation group was lower than those in the con-trol group,and the differences were statistically significant(all P<0.05).There was no significant difference in the rate of total adverse drug reactions between the two groups(P>0.05).Conclusion The combination of methylprednisolone and azithromycin can improve the therapeutic effect of MPP in children,accelerate the remission of pneumonia symp-toms,reduce the inflammatory reaction,and ensure the safety of medication.
Severe mycoplasma pneumoniae pneumonia in childrenMethylprednisoloneAzithromycinBody inflammation
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