Evaluation of the Effect of Piracetam Injection Combined with Mannitol Treatment of Cerebral Edema after Traumatic Brain Injury
Objective To investigate the clinical value of piracetam injection combined with mannitol in the treatment of patients with cerebral edema after traumatic brain injury.Methods A total of 84 patients with cerebral edema after traumatic brain injury admitted to Binzhou Second People's Hospital from June 2022 to December 2023 were ran-domly selected as the study subjects.The patients were divided into reference group and study group by add-even grouping method,with 42 cases in each group.The patients in the reference group were treated with mannitol,and the patients in the study group were treated with piracetam injection combined with mannitol.The serological indexes,im-aging indexes and clinical effects of the two groups were analyzed.Results After treatment,the neurological function score of the study group was lower than that of the reference group,and the cognitive function score was higher than that of the reference group,the differences were statistically significant(both P<0.05).After treatment,the cerebral edema volume was(2.32±0.20)mL,edema volume was(2.41±0.24)mL in the study group,which were lower than those in the reference group,and the differences were statistically significant(t=49.513,33.191,both P<0.05).After treatment,the results of neuron-specific enolase and aquaporin 4 related serological indexes in the study group were lower than those in the reference group,the differences were statistically significant(all P<0.05).Conclusion Pirace-tam injection combined with mannitol has a significant effect on improving the neurological function of patients with cerebral edema after traumatic brain injury,and it is helpful to reduce the volume of brain edema.
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