Study on the Effect of Multifaceted Administration of Poractant Alaf Injec-tion in The Treatment of Neonatal Respiratory Distress Syndrome
Objective To explore the application effect of multi-directional administration of Poractant Alfa injection in the treatment of Neonatal Respiratory Distress Syndrome(NRDS).Methods A total of 60 children with NRDS ad-mitted to Putian Children's Hospital from June 2021 to June 2023 were simple randomly selected as the research ob-jects.The children were divided into control group and study group by envelope method,with 30 cases in each group.The children in the control group were treated with intratracheal instillation of poractant alfa injection,and the chil-dren in the study group were treated with multi-directional administration of poractant alfa injection.The clinical effi-cacy,blood oxygen level and complication rate of the two groups were compared under different treatment measures.Results The total effective rate of the observation group(96.67%)was higher than that of the control group,the differ-ence was statistically significant(χ2=4.043,P<0.05).Before treatment,there was no significant difference in blood oxygen saturation(SaO2),arterial partial pressure of oxygen(PaO2),arterial carbon dioxide partial pressure(PaCO2),and total carbon dioxide(TCO2)between the two groups(all P>0.05).After 24 hous of treatment,the arterial blood gas analysis indexes of the two groups were compared,and the SaO2 level was(93.65±4.15)%and PaO2 level was(85.63±2.41)mmHg in the study group,which were higher than those in the control group.PaCO2 level was(43.65±2.24)mmHg and TCO2 level was(35.41±2.81)mmHg,which were lower than those of control group,the differences were sta-tistically significant(t=2.471,2.674,3.370,2.897,all P<0.05).There was no significant difference in the total inci-dence of complications between the two groups(P>0.05).Conclusion Poractant alfa injection is more effective than in-tratracheal instillation in the treatment of neonatal distress syndrome in children.It can improve arterial blood gas in-dex and effectively control the risk of complications.
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