The Application of Hydromorphone Combined with Sufentanil in Patients with Video-assissted Thoracoscopic Lobectomy
Objective To investigate the application effect of hydromorphone combined with sufentanil in patients un-dergoing thoracoscopic lobectomy.Methods A total of 116 patients undergoing video-assissted thoracoscopic lobec-tomy admitted to Kashgar People's Hospital from November 2022 to December 2023 were conveniently selected as the research objects.According to different anesthesia schemes,they were divided into control group and study group,with 58 cases in each group.The patients in the control group were given sufentanil anesthesia,and the patients in the study group were combined with hydromorphone anesthesia.The hemodynamic changes at different times,the changes of physiological stress indexes,the postoperative analgesic effect and the incidence of adverse events were compared between the two groups.Results There was no significant difference in mean arterial pressure(MAP)and heart rate(HR)between the two groups before procedure(T0)(both P>0.05).At intubation(T1),intubation for 5 min(T2),extu-bation(T3)and end of operaction(T4),the MAP and HR levels in the study group were lower than those in the control group,the differences were statistically significant(all P<0.05).The levels of physiological stress indexes in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The scores of Visual Analogue Scale in the study group were lower than those in the control group at 1 h,6 h and 24 h af-ter operation,and the differences were statistically significant(all P<0.05).The total incidence of adverse events in the study group was 5.17%(3/58),which was lower than that in the control group 17.24%(10/58),and the difference was statistically significant(χ2=4.245,P<0.05).Conclusion Hydromorphone combined with sufentanil anesthesia in thoracoscopic lobectomy is helpful to maintain hemodynamic stability,reduce the risk of stress response and adverse events,and improve postoperative analgesia.
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