Analysis of the Application Value of Non-invasive High Frequency Ventila-tion Combined with Caffeine in Weaning from Respiratory Distress Syn-drome in Newborns
Objective To analyze the application value of non-invasive high-frequency ventilation(NHFV)combined with caffeine in weaning of neonatal respiratory distress syndrome(NRDS).Methods A total of 100 children with NRDS admitted to the Department of Neonatology,Anxi County Hospital from January 2021 to December 2023 were randomly selected as the research objects.They were divided into two groups by different treatment methods,with 50 cases in each group.The control group was treated with nasal continuous positive airway pressure(NCPAP)combined with caffeine after weaning.The study group was treated with NHFV combined with caffeine after weaning.The suc-cess rate of weaning,the situation after weaning and blood gas analysis indexes were compared between the two groups.Results The success rate of weaning in the study group was 98.00%(49/50),which was higher than 86.00%(43/50)in the control group,and the difference was statistically significant(χ2=4.891,P=0.027).The number of ap-neas within 72 hours in the study group was less than that in the control group,and the oxygen time,ventilation time and hospitalization time were shorter than those in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in pH value between the two groups at 1 h and 12 h after mechanical ventila-tion withdrawal(both P>0.05);at 1 hour and 12 hours after weaning,the arterial oxygen partial pressure in the study group was higher than that in the control group,and the arterial carbon dioxide partial pressure was lower than that in the control group,the differences were statistically significant(both P<0.05).Conclusion The application of NHFV combined with caffeine in NRDS weaning is helpful to improve the success rate of weaning,and can improve respira-tory function,reduce ventilation time and hospitalization time,without affecting the acid-base balance of patients.
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