Analysis of the Clinical Effect of Vonoprazan Fumarate Tablets in the Treatment of Patients with Recurrent Reflux Esophagitis
Objective To evaluate the clinical effect of fumarate tablet in the treatment of patients with recurrent re-flux esophagitis.Methods A total of 70 patients with recurrent reflux esophagitis admitted to Meitan County People's Hospital from January 2023 to January 2024 were simple randomly selected as the research objects.They were di-vided into observation group and control group by different therapeutic methods,with 35 cases in each group.The con-trol group was treated with omeprazole enteric-coated capsules,and the observation group was treated with vonopra-zan fumarate tablets.The differences in gastrointestinal hormone indexes,gastroscopy grading and the state of symp-tom improvement between the two groups were compared.Results After treatment,the gastrointestinal hormone indexes(gastrin and motilin)of the two groups increased,the gastrin and motilin in the observation group were(284.53±17.75)pg/mL and(125.66±8.05)ng/L,respectively,which were higher than(241.82±16.44)pg/mL and(118.85±7.14)ng/L in the control group,the differences were statistically significant(t=10.443,3.744,all P<0.05).The gastroscopy grading of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of substernal burning pain,heartburn and acid regurgitation in the two groups de-creased,and those in the observation group were lower than the control group,the differences were statistically signifi-cant(all P<0.05).Conclusion In the treatment of patients with recurrent reflux esophagitis,fumarate tablet can im-prove gastrointestinal hormone indexes,gastroscopy results and clinical symptoms more effectively,showing better therapeutic effect.
万方数据
维普
