Efficacy Analysis of Azithromycin Combined with Montelukast Sodium in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children
Objective To investigate the efficacy of azithromycin combined with Montelukast sodium in the treatment of mycoplasmal pneumonia(MPP)in children.Methods A total of 74 children with MPP admitted to Juye County Hos-pital of Traditional Chinese Medicine from March 2023 to March 2024 were conveniently selected as study objects and divided into group A and group B by differnet therapeutic methods,with 37 cases in each group.Group A was treated with azithromycin sequential therapy,and group B was treated with montelukast sodium on the basis of group A.The total effective rate,adverse drug reactions,symptom disappearance time,inflammatory factors and immune function were compared between the two groups.Results The total effective rate of group B was 97.30%(36/37),which was higher than 78.38%(29/37)of group A,and the difference was statistically significant(χ2=4.554,P<0.05).The disappearance time of fever,wheezing,cough and pulmonary rales in group B were all shorter than that in group A,and the differences were statistically significant(all P<0.05).The levels of procalcitonin,C-reactive protein,immu-noglobulin E and immunoglobulin G in group B were lower than those in group A,and the level of immunoglobulin A was higher than that in group A the the differences were statistically significant(all P<0.05).The total adverse drug re-action in group B was 10.81%(4/37),which was higher than 8.11%(3/37)of group A,but the difference was not statis-tically significant(χ2=0.000,P>0.05).Conclusion The combination of azithromycin and montelukast sodium in the treatment of MPP in children can significantly enhance the curative effect,shorten the recovery time of symptoms,and have a positive effect on the improvement of inflammatory factors and immune indexes,and have a lower adverse drug reaction rate.
AzithromycinMontelukast sodiumMycoplasma pneumonia in childrenInflammatory factorsImmune function
万方数据
维普
