Objective To evaluate the clinical efficacy of flurbiprofen axetil combined with nalbuphine for preemptive analgesia in laparoscopic cholecystectomy(LC).Methods Clinical data of 90 patients undergoing LC in Luoyang Cen-tral Hospital from August 2022 to October 2023 were retrospectively selected.They were divided into nalbuphine group(group A,n=30),flurbiprofen exate group(group B,n=30)and nalbuphine combined with flurbiprofen exate group(group C,n=30)according to different narcotic drugs.Pre-analgesic drugs were given 15 min before surgical in-cision.Patients in group A were given intravenous infusion of nalbuphine 0.2 mg/kg,patients in group B were given in-travenous infusion of flurbiprofen ester 2 mg/kg,and patients in group C were given intravenous infusion of nalbuphine 0.2 mg/kg and flurbiprofen ester 2 mg/kg.Visual Analogue Scale(VAS)scores and Ramsay sedation scores were ob-tained 2 h(T1),4 h(T2),12 h(T3)and 24 h(T4)after surgery,the dose of propofol and remifentanil used during sur-gery,the time to recovery after discontinuation of the drug,the score of postoperative recovery quality[assessed by Quality of Recovery-15 Score(QoR-15)scale],and the incidence of postoperative adverse reactions of three groups were compared.Results There was no significant difference in the dosage of propofol and recovery time among 3 groups(both P＞0.05).The dosage of remifentanil in group C was lower than that in group A and group B,and the dif-ference was statistically significant(P＜0.05).The VAS scores at T1 and T2 time points in group C were lower than those in group A and group B,and the differences were statistically significant(both P＜0.05).There was no significant difference in T3 and T4 VAS scores among 3 groups(both P＞0.05).There was no significant difference in Ramsay score at T1 to T4 in 3 groups(all P＞0.05).The QoR-15 scores in group C were significantly higher than those in group A and group B on the 1st and 3rd day after surgery,the differences were statistically significant(both P＜0.05).There was no significant difference in the total incidence of postoperative adverse reactions(nausea,vomiting,chills,pruritus and respiratory depression)among 3 groups(all P＞0.05).Conclusion Flurbiprofen axetil combined with nal-buphine can provide good intraoperative analgesia effect in LC,and can inhibit early postoperative pain,improve post-operative quality of life and accelerate recovery.The combined application has high safety,and can provide reference for perioperative analgesia management in patients with laparoscopic cholecystectomy.
维普
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