Application of Flurbiprofen Axetil Combined with Nalbuphine Preemptiue Analgesia in Laparoscopic Cholecystectomy
Objective To evaluate the clinical efficacy of flurbiprofen axetil combined with nalbuphine for preemptive analgesia in laparoscopic cholecystectomy(LC).Methods Clinical data of 90 patients undergoing LC in Luoyang Cen-tral Hospital from August 2022 to October 2023 were retrospectively selected.They were divided into nalbuphine group(group A,n=30),flurbiprofen exate group(group B,n=30)and nalbuphine combined with flurbiprofen exate group(group C,n=30)according to different narcotic drugs.Pre-analgesic drugs were given 15 min before surgical in-cision.Patients in group A were given intravenous infusion of nalbuphine 0.2 mg/kg,patients in group B were given in-travenous infusion of flurbiprofen ester 2 mg/kg,and patients in group C were given intravenous infusion of nalbuphine 0.2 mg/kg and flurbiprofen ester 2 mg/kg.Visual Analogue Scale(VAS)scores and Ramsay sedation scores were ob-tained 2 h(T1),4 h(T2),12 h(T3)and 24 h(T4)after surgery,the dose of propofol and remifentanil used during sur-gery,the time to recovery after discontinuation of the drug,the score of postoperative recovery quality[assessed by Quality of Recovery-15 Score(QoR-15)scale],and the incidence of postoperative adverse reactions of three groups were compared.Results There was no significant difference in the dosage of propofol and recovery time among 3 groups(both P＞0.05).The dosage of remifentanil in group C was lower than that in group A and group B,and the dif-ference was statistically significant(P＜0.05).The VAS scores at T1 and T2 time points in group C were lower than those in group A and group B,and the differences were statistically significant(both P＜0.05).There was no significant difference in T3 and T4 VAS scores among 3 groups(both P＞0.05).There was no significant difference in Ramsay score at T1 to T4 in 3 groups(all P＞0.05).The QoR-15 scores in group C were significantly higher than those in group A and group B on the 1st and 3rd day after surgery,the differences were statistically significant(both P＜0.05).There was no significant difference in the total incidence of postoperative adverse reactions(nausea,vomiting,chills,pruritus and respiratory depression)among 3 groups(all P＞0.05).Conclusion Flurbiprofen axetil combined with nal-buphine can provide good intraoperative analgesia effect in LC,and can inhibit early postoperative pain,improve post-operative quality of life and accelerate recovery.The combined application has high safety,and can provide reference for perioperative analgesia management in patients with laparoscopic cholecystectomy.
万方数据
维普
