Analysis of the Efficacy of Aspirin Combined with Clopidogrel Bisulfate in the Treatment of Cerebral Infarction
Objective To explore the application value of aspirin combined with clopidogrel bisulfate in the treatment of patients with cerebral infarction.Methods A total of 116 patients with cerebral infarction admitted to Shanxian Cen-tral Hospital from February 2022 to October 2023 were conveniently selected as the research objects.They were di-vided into control group(n=58,aspirin)and study group(n=58,aspirin+clopidogrel bisulfate)by different treatment.The treatment efficiency,neurological deficit,cognitive and daily living ability scores,inflammatory factor levels,and coagulation function of the two groups were compared.Results The total effective rate of treatment in the study group was 94.83%(55/58),which was higher than 81.03%(47/58)in the control group,and the difference was statistically significant(χ2=5.199,P＜0.05).The neurological deficit score of the study group was lower than that of the control group,and the cognitive function score and daily living ability score were higher than those of the control group,the differences were statistically significant(all P＜0.05).The levels of interleukin-6,C-reactive protein and tumor necro-sis factor-α in the study group were lower than those in the control group,and the differences were statistically signifi-cant(all P＜0.05).The fibrinogen in the study group was lower than that in the control group,and the thrombin time,prothrombin time and activated partial thrombin time were higher than those in the control group,and the differences were statistically significant(all P＜0.05).Conclusion The combination of aspirin and clopidogrel bisulfate in the treat-ment of cerebral infarction can improve the clinical efficacy,reduce the inflammatory reaction,improve the hemody-namics and coagulation function,reduce the neurological deficit,and have a positive effect on improving the cognitive function and improving the living ability.
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