Clinical Effect of Agomelatine Combined with Mirtazapine in the Treat-ment of Depression
Objective To analyze the value of using mirtazapine and agomelatine for the treatment of depression.Methods 80 patients with depression admitted to the Quanzhou Third Hospital were simple randomly selected as samples from January 2020 to October 2022.According to different treatment methods,they were divided into two groups,40 cases in each group.The control group was treated with mirtazapine tablets alone,while the observation group was treated with agomelatine tablets combined with mirtazapine tablets.The clinical efficacy,Hamilton Depres-sion Scale(HAMD)score,Pittsburgh Sleep Quality Index(PSQI)score,neurotransmitter and oxidative stress indica-tors,and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the obser-vation group was 95.00%(38/40),which was higher than that of control group[72.50%(29/40)]and the difference was statistically significant(χ2=7.440,P＜0.05).At 2 weeks,4 weeks,6 weeks and 8 weeks of treatment,HAMD scores and PSQI scores in observation group were lower than those in control group,and the differences were statistically sig-nificant(all P＜0.05).After treatment,the levels of 5-hydroxytryptamine,norepinephrine and superoxide dismutase in observation group were higher than those in control group,while the levels of dopamine and malondialdehyde were lower than those in control group,the differences were statistically significant(all P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The clinical effect of combining agomelatine tablets with mirtazapine tablets in the treatment of depression is significant.It can regulate brain neurotransmitters,regulate oxidative stress response,effectively alleviate depressive symptoms,improve sleep quality,and has positive clinical significance.
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维普
