Evaluation of Clinical Efficacy of Aripiprazole Orally Disintegrating Tab-lets Combined with Fluvoxamine Maleate Tablets in the Treatment of Schizophrenia
Objective To observe the clinical efficacy of aripiprazole orally disintegrating tablets combined with flu-voxamine maleate tablets in the treatment of schizophrenia.Methods A total of 80 patients with schizophrenia admit-ted to Qiandongnan Psychiatric Hospital from January 2019 to December 2023 were randomly selected and divided into control group and observation group by different treatment methods,with 40 cases in each group.The control group was only treated with aripiprazole orally disintegrating tablets,while the observation group was treated with ar-ipiprazole orally disintegrating tablets combined with fluvoxamine maleate tablets.The clinical efficacy,Modified Overt Aggression Scale(MOAS)score,Personal Social Performance Scale(PSP)score and incidence of adverse reac-tions were compared between the two groups.Results After administration,the clinical efficacy of the observation group[97.50%(39/40)]was higher than that of the control group[80.00%(32/40)],and the difference was statistically significant(χ2=4.507,P＜0.05).The MOAS score of the observation group(3.32±0.31)points was lower than that of the control group[(6.63±0.45)points],and the PSP[(85.88±7.52)points]was higher than that of the control group[(70.78±9.17)points],the differences were statistically significant(all P＜0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Aripiprazole orally disintegrating tab-lets combined with fluvoxamine maleate tablets can significantly improve the overall therapeutic effect,explicit aggres-sive behavior and social function of patients with schizophrenia,with high safety.
万方数据
维普
