Safety Analysis of Anticoagulant Treatment Regimen after Intravenous Thrombolysis in Patients with Acute Cerebral Infarction
Objective To explore the safety of anticoagulation therapy after intravenous thrombolysis in patients with cerebrovascular accidents.Methods From January 2021 to January 2024,100 patients with acute cerebral infarction who received intravenous thrombolytic therapy in Jiaxiang County People's Hospital were randomly selected as the re-search objects.According to the different treatment methods,they were divided into two groups,50 cases in each group.The control group was treated with dual antiplatelet therapy after intravenous thrombolysis,and the study group was treated with anticoagulant therapy after intravenous thrombolysis,and then given dual antiplatelet therapy.The co-agulation time,hemorheological indexes,neurological function,limb function,Karnofsky Performance Status,daily liv-ing ability,prognosis and incidence of bleeding events were compared between the two groups.Results After treat-ment,the coagulation time indexes of the study group were longer than those of the control group,the hemorheological indexes and neurological function scores of the study group were lower than those of the control group,the scores of limb function,Karnofsky Performance Status and daily living ability of the study group were higher than those of the control group,and the differences were statistically significant(all P＜0.05).The good prognosis rate of the study group[96.00%(48/50)]was higher than that of the control group[82.00%(41/50)],and the difference was statistically sig-nificant(χ2=5.005,P＜0.05).The incidence of cerebral hemorrhage,nasal hemorrhage and gastrointestinal hemorrhage in the study group was 4.00%(2/50),8.00%(4/50)and 0,respectively,compared with 2.00%(1/50),6.00%(3/50)and 2.00%(1/50)in the control group,the differences were not statistically significant(χ2=0.000,0.000,0.000,all P＞0.05).Conclusion After intravenous thrombolysis treatment in patients with acute cerebral infarction,anticoagulant therapy should be given first,followed by dual antiplatelet therapy.This can effectively exert anticoagulant effects,im-prove the patient's hemorheology,promote the recovery of neurological function,limb function,and daily living ability,and lead to improved prognosis without increasing the risk of bleeding.The safety is good.
万方数据
维普
