目的 探讨预防性使用枸橼酸咖啡因对晚期早产儿血氧波动及神经发育结局的影响.方法 方便选择2020年1月—2023年12月丹阳市妇幼保健院收治的78例晚期早产儿为研究对象,根据不同的治疗方法分为观察组和对照组,各39例.观察组予以枸橼酸咖啡因注射液治疗,对照组予以常规治疗.比较两组患儿的血气分析指标、振幅整合脑电图(amplitude-integrated electroencephalogram,aEEG)异常率、磁共振成像(mag-netic resonance imaging,MRI)综合评分、辅助通气时间、住院时间、呼吸暂停发生率、不良反应发生率及行为神经评分(Neonatal Behavioral Neurological Assessment,NBNA)和婴幼儿智能发育测试结果(China's Develop-mental Center for Children,CDCC).结果 观察组的动脉血氧饱和度、动脉血氧分压、二氧化碳分压、NBNA评分、CDCC评分、MRI综合评分均优于对照组,差异有统计学意义(P均<0.05).观察组的aEGG异常率为2.56%(1/39),低于对照组的20.51%(8/39),差异有统计学意义(χ2=4.522,P=0.033).两组不良反应发生率比较,差异无统计学意义(P>0.05).观察组呼吸暂停发生率低于对照组,差异有统计学意义(P<0.05).观察组的辅助通气时间和住院时间均短于对照组,差异有统计学意义(P均<0.05).结论 预防性使用枸橼酸咖啡因可明显改善晚期早产儿氧合能力,并保护脑组织,促进神经发育.
Clinical Study on Preventive Use of Caffeine Citrate to Improve Blood Oxygen Fluctuation and Neurodevelopmental Outcome in Late Preterm In-fants
Objective To investigate the effect of preventive use of caffeine citrate on blood oxygen fluctuation and neurodevelopmental outcome in late preterm infants.Methods A total of 78 late preterm infants admitted to Danyang Maternal and Child Health Hospital from January 2020 to December 2023 were conveniently selected as the research objects.They were divided into observation group and control group by different treatment methods,with 39 cases in each group.The observation group was treated with caffeine citrate injection,and the control group was treated with routine treatment.The blood gas indexes,abnormal rate of amplitude-integrated electroencephalogram(aEEG),com-prehensive score of magnetic resonance imaging(MRI),assisted ventilation time,hospitalization time,incidence of ap-nea,incidence of adverse events,Neonatal Behavioral Neurological Assessment(NBNA)and China's Developmental Center for Children(CDCC)were compared between the two groups.Results The arterial oxygen saturation,arterial oxygen partial pressure,carbon dioxide partial pressure,NBNA score,CDCC scores,compresire scores of MRI of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).The abnormal rate of aEGG in the observation group was 2.56%(1/39),which was lower than 20.51%(8/39)in the control group,and the difference was statistically significant(χ2=4.522,P=0.033).There was no significant differ-ence in the incidence of adverse reactions between the two groups(P>0.05).The incidence of apnea in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).The auxiliary venti-lation time and hospitalization time of the observation group were shorter than those of the control group,and the dif-ferences were statistically significant(both P<0.05).Conclusion Preventive use of caffeine citrate can significantly im-prove the oxygenation capacity of late preterm infants,protect brain tissue and promote neurodevelopment.
万方数据
维普
