Objective To investigate the clinical effect of non-invasive ventilator combined with caffeine citrate on pri-mary apnea of premature infants.Methods A total of 82 premature infants with primary apnea admitted to the Emer-gency Department of Pizhou Hospital of Traditional Chinese Medicine from January 2021 to September 2023 were con-veniently selected as the study subjects.They were divided into control group and study group according to different treatment methods,with 41 cases in each group.The control group was treated with simple non-invasive ventilator as-sisted breathing,and the study group was treated with non-invasive ventilator assisted ventilation combined with caf-feine citrate.The treatment efficiency,blood index,clinical indicators,complications and number of apnea attack in 24 h of the two groups was compared.Results After treatment,there was no significant difference in the incidence of complications between two groups(χ2=0.064,P=0.800).The blood oxygen partial pressure of the study group was higher than that of the control group,and the carbon dioxide partial pressure and respiratory rate were lower than that of the control group,the differences were statistically significant(all P<0.05).The effective rate of the study group[97.56%(40/41)]was higher than that of the control group[85.37%(35/41)],and the difference was statistically sig-nificant(χ2=3.905,P=0.048).The total oxygen consumption time,hospitalization time,withdrawal time and apnea dis-appearance time of the study group were shorter than those of the control group,and the differences were statistically significant(all P<0.05).The number of apnea attacks in 24 h in the study group was less than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Ventilator assisted ventilation combined with caf-feine citrate is effective for premature infants with primary apnea.
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