首页|盐酸左西替利嗪联合孟鲁司特钠治疗儿童过敏性咳嗽的疗效分析

盐酸左西替利嗪联合孟鲁司特钠治疗儿童过敏性咳嗽的疗效分析

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目的 分析联合运用盐酸左西替利嗪联合孟鲁司特钠治疗儿童过敏性咳嗽的临床疗效.方法 便利选取2022年1月—2023年12月漳浦县妇幼保健院儿童保健科收治的62例过敏性咳嗽患儿为研究对象,按照不同治疗方法分为对比组与研究组,每组31例.对比组使用孟鲁司特钠治疗,研究组在此基础上联合运用盐酸左西替利嗪治疗,比较两组临床疗效、不良反应、咳嗽评分、免疫指标.结果 研究组治疗总有效率96.77%(30/31)高于对比组的74.19%(23/31),差异有统计学意义(χ2=4.679,P=0.031).两组患儿不良反应总发生率对比,差异无统计学意义(P>0.05).治疗前,两组患儿咳嗽评分对比,差异无统计学意义(P>0.05);治疗后,研究组夜间咳嗽评分、日间咳嗽评分较对比组均更低,差异有统计学意义(P均<0.05).治疗后,研究组补体C3(complement 3)、总免疫球蛋白A(immunoglobulin A,IgA)水平较对比组均更高,而总免疫球蛋白E(immunoglobulin E,IgE)水平较对比组更低,差异有统计学意义(P均<0.05).结论 为过敏性咳嗽患儿实施治疗期间联合运用孟鲁司特钠与盐酸左西替利嗪,有助于提升临床疗效,缓解患儿的咳嗽症状,利于调节机体免疫.
Analysis of the Therapeutic Effect of Levocetirizine Dihydrochoride Com-bined with Montelukast Sodium in the Treatment of Allergic Cough in Children
Objective To analyze the clinical efficacy of levocetirizine dihydrochoride combined with montelukast so-dium in the treatment of allergic cough in children.Methods A total of 62 children with allergic cough admitted to the Department of Children'S Health Care of Zhangpu County Maternal and Child Health Hospital from January 2022 to December 2023 were conveniently selected as the research objects.The children were divided into the control group and the study group according to the difference treatment methods,with 31 cases in each group.The control group was treated with montelukast sodium,and the study group was treated with levocetirizine dihydrochoride on this basis.The clinical efficacy,adverse reactions,cough scores and immune indexes were compared between the two groups.Results the study group were lower than those of the control group,and the differences were statistically significant(both P<0.05).After treatment,the levels of complement 3(C3)and total immunoglobulin A(IgA)in the study group were higher than those in the control group,while the total immunoglobulin E(IgE)level was lower than that in the control group,and the differences were statistically significant(all P<0.05).Conclusion The combined use of montelukast so-dium and levocetirizine hydrochloride during the treatment of children with allergic cough can help improve the clini-cal efficacy,relieve the cough symptoms of children,and help regulate the body's immunity.

Allergic coughMontelukast sodiumLevocetirizine dihydrochoride

陈玉香

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漳浦县妇幼保健院儿童保健科,福建 漳浦 363200

过敏性咳嗽 孟鲁司特钠 盐酸左西替利嗪

2024

中外医疗
卫生部医院管理研究所 二十一世纪联合创新医药科学研究院

中外医疗

影响因子:0.909
ISSN:1674-0742
年,卷(期):2024.43(23)