Clinical Effect Analysis of Invasive Mechanical Ventilation Combined with Transnasal High-flow Oxygen Humidification Therapy in Elderly Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Objective To explore the clinical effect of invasive mechanical ventilation combined with high-flow nasal cannula(HFNC)in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 60 elderly patients with AECOPD admitted to Zoucheng People's Hospital from January 2022 to December 2023 were randomly selected as the research objects.They were divided into noninvasive positive pressure ventilation(NIPPV)group and HFNC group according to different ventilation methods,with 30 cases in each group.Both groups were treated with invasive mechanical ventilation.After meeting the offline criteria,the NIPPV group was treated with NIPPV sequential therapy,and the HFNC group was treated with HFNC sequential therapy.The blood gas index level,respiratory function and total incidence of adverse reactions were compared between the two groups.Results After 1 week of treatment,the blood gas level and lung function level in the HFNC group were better than those in the NIPPV group,and the differences were statistically significant(both P<0.05).The total incidence of com-plications in the HFNC group was 10.00%(3/30)lower than 33.33%(10/30)in the NIPPV group,and the difference was statistically significant(χ2=4.812,P<0.05).Conclusion For elderly patients with AECOPD,invasive mechanical ventilation combined with nasal high-flow oxygen humidification can effectively improve the blood gas level and lung function of patients,and reduce the incidence of adverse reactions.
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